ENSMUSG00000044716


Mus musculus

Features
Gene ID: ENSMUSG00000044716
  
Biological name :Dok7
  
Synonyms : Dok7 / Mus musculus docking protein 7 (Dok7), transcript variant 4, mRNA. / Q18PE0
  
Possible biological names infered from orthology : docking protein 7 / Q18PE1
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B2
Gene start: 35056766
Gene end: 35087839
  
Corresponding Affymetrix probe sets: 10521371 (MoGene1.0st)   1434812_s_at (Mouse Genome 430 2.0 Array)   1442869_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116023
Ensembl peptide - ENSMUSP00000059538
Ensembl peptide - ENSMUSP00000098856
Ensembl peptide - ENSMUSP00000109909
NCBI entrez gene - 231134     See in Manteia.
MGI - MGI:3584043
RefSeq - XM_017320832
RefSeq - NM_001348274
RefSeq - NM_001348275
RefSeq - NM_001348276
RefSeq - NM_001348478
RefSeq - NM_172708
RefSeq - XM_006503898
RefSeq - XM_006503899
RefSeq - XM_006503900
RefSeq Peptide - NP_001335407
RefSeq Peptide - NP_001335203
RefSeq Peptide - NP_001335204
RefSeq Peptide - NP_766296
RefSeq Peptide - NP_001335205
swissprot - Q18PE0
swissprot - D3Z7E3
swissprot - A0A0R4J0R2
Ensembl - ENSMUSG00000044716
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dok7ENSDARG00000060236Danio rerio
 DOK7ENSGALG00000015615Gallus gallus
 DOK7ENSG00000175920Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR002404  IRS-type PTB domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0007528 neuromuscular junction development IGI
 biological_processGO:0043113 receptor clustering IGI
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031594 neuromuscular junction IDA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/Apc+,Msh2tm1Mak/Msh2tm1Mak,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
Show

Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
Show

Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

Allelic Composition: Dok7tm2Yyam/Dok7tm2Yyam
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: ApcMin/Apc+,Msh2tm1Mak/Msh2tm1Mak,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: ApcMin/Apc+,Msh2tm1Mak/Msh2tm1Mak,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/Apc+,Msh2tm1Mak/Msh2tm1Mak,Nos2tm1Mrl/Nos2tm1Mrl
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0002690 akinesia "absence of movement or loss of the ability to move such as temporary or prolonged paralysis or "freezing in place"" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:82238]
Show

Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Itgb1tm2Son/Itgb1tm2Son
Genetic Background: FVB.129P2-Itgb1tm2Son

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0011968 decreased threshold for auditory brainstem response "reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [MGI:csmith]
Show

Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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