ENSMUSG00000044748


Mus musculus

Features
Gene ID: ENSMUSG00000044748
  
Biological name :Defb1
  
Synonyms : Beta-defensin 1 / Defb1 / P56386
  
Possible biological names infered from orthology : defensin beta 1 / P60022
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A2
Gene start: 21776599
Gene end: 21795185
  
Corresponding Affymetrix probe sets: 10570741 (MoGene1.0st)   1419491_at (Mouse Genome 430 2.0 Array)   1419492_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051754
NCBI entrez gene - 13214     See in Manteia.
MGI - MGI:1096878
RefSeq - NM_007843
RefSeq Peptide - NP_031869
swissprot - P56386
swissprot - Q3UQE2
Ensembl - ENSMUSG00000044748
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DEFB1ENSG00000164825Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001855  Beta defensin type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002526 acute inflammatory response IEA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0009617 response to bacterium IMP
 biological_processGO:0019933 cAMP-mediated signaling ISS
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0035584 calcium-mediated signaling using intracellular calcium source ISS
 biological_processGO:0042742 defense response to bacterium ISO
 biological_processGO:0045087 innate immune response IMP
 biological_processGO:0050829 defense response to Gram-negative bacterium ISS
 biological_processGO:0050830 defense response to Gram-positive bacterium ISS
 biological_processGO:0060474 positive regulation of flagellated sperm motility involved in capacitation ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane ISS
 cellular_componentGO:0097225 sperm midpiece ISS
 cellular_componentGO:1990742 microvesicle ISS
 molecular_functionGO:0031731 CCR6 chemokine receptor binding ISS
 molecular_functionGO:0042802 identical protein binding ISS


Pathways (from Reactome)
Pathway description
Beta defensins
Defensins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Tg(Mpz-cre)1Brn/0
Genetic Background: involves: FVB/N

Allelic Composition: Defb1tm1Jmw/Defb1+
Genetic Background: B6.129S5-Defb1tm1Jmw

 MP:0010386 abnormal urinary bladder physiology "any functional anomaly of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Phlda2tm2Bty/Phlda2tm2Bty,Phlda3tm1Bty/Phlda3tm1Bty
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Erbb2tm1Klee/Erbb2tm1Klee,Tg(Mpz-cre)1Brn/0
Genetic Background: involves: FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000040899 Ccr6 / O54689 / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA. / P51684* / C-C motif chemokine receptor 6*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr