ENSMUSG00000045636


Mus musculus

Features
Gene ID: ENSMUSG00000045636
  
Biological name :Mtus1
  
Synonyms : mitochondrial tumor suppressor 1 / Mtus1
  
Possible biological names infered from orthology : microtubule associated scaffold protein 1 / Q9ULD2
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A4
Gene start: 40990914
Gene end: 41133726
  
Corresponding Affymetrix probe sets: 10578324 (MoGene1.0st)   1436501_at (Mouse Genome 430 2.0 Array)   1436502_at (Mouse Genome 430 2.0 Array)   1454824_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059503
Ensembl peptide - ENSMUSP00000121605
Ensembl peptide - ENSMUSP00000119440
Ensembl peptide - ENSMUSP00000119163
Ensembl peptide - ENSMUSP00000116339
Ensembl peptide - ENSMUSP00000113082
Ensembl peptide - ENSMUSP00000112626
Ensembl peptide - ENSMUSP00000091252
Ensembl peptide - ENSMUSP00000053554
NCBI entrez gene - 102103     See in Manteia.
MGI - MGI:2142572
RefSeq - XM_006509241
RefSeq - NM_001005863
RefSeq - NM_001005864
RefSeq - NM_001005865
RefSeq - NM_001286413
RefSeq - XM_006509239
RefSeq - XM_006509240
RefSeq Peptide - NP_001005864
RefSeq Peptide - NP_001005863
RefSeq Peptide - NP_001005865
RefSeq Peptide - NP_001273342
swissprot - A0A0R4J1L9
swissprot - A0A0R4J147
swissprot - A0A0R4J0N9
swissprot - D3Z7B3
swissprot - F6Q593
swissprot - E9Q8N4
swissprot - D3Z2Y9
swissprot - D3Z2H5
Ensembl - ENSMUSG00000045636
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mtus1aENSDARG00000071562Danio rerio
 mtus1bENSDARG00000034105Danio rerio
 ENSGALG00000013615Gallus gallus
 MTUS1ENSG00000129422Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mtus2 / Q3UHD3 / Microtubule-associated tumor suppressor candidate 2 homolog / Q5JR59* / microtubule associated scaffold protein 2*ENSMUSG0000002965116
Ccdc69 / Q3TCJ8 / Coiled-coil domain-containing protein 69 / A6NI79* / coiled-coil domain containing 69*ENSMUSG000000495884


Protein motifs (from Interpro)
Interpro ID Name
 IPR029786  Microtubule-associated tumour suppressor 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
Show

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stat4ity14/Stat4ity14
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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