ENSMUSG00000045915


Mus musculus

Features
Gene ID: ENSMUSG00000045915
  
Biological name :Ccdc42
  
Synonyms : Ccdc42 / Coiled-coil domain-containing protein 42 / Q5SV66
  
Possible biological names infered from orthology : coiled-coil domain containing 42 / Q96M95
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 68587021
Gene end: 68597966
  
Corresponding Affymetrix probe sets: 10377310 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000057342
Ensembl peptide - ENSMUSP00000099672
Ensembl peptide - ENSMUSP00000114381
NCBI entrez gene - 276920     See in Manteia.
MGI - MGI:3045254
RefSeq - XM_006533483
RefSeq - NM_177779
RefSeq Peptide - NP_808447
swissprot - Q5SV65
swissprot - Q5SV66
Ensembl - ENSMUSG00000045915
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CCDC42ENSGALG00000043975Gallus gallus
 CCDC42ENSG00000161973Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cfap73 / J3QPZ5 / Cilia- and flagella-associated protein 73 / A6NFT4*ENSMUSG0000009428228


Protein motifs (from Interpro)
Interpro ID Name
 IPR025252  Domain of unknown function DUF4200


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007286 spermatid development IMP
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Mgat1tm2Jxm/Mgat1tm2Jxm,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Mgat1tm2Jxm/Mgat1tm2Jxm,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Mgat1tm2Jxm/Mgat1tm2Jxm,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Mgat1tm2Jxm/Mgat1tm2Jxm,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004182 abnormal spermiation "failure of mature spermatozoa to release from supporting Sertoli cells into the lumen of seminiferous tubules" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Mgat1tm2Jxm/Mgat1tm2Jxm,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Mgat1tm2Jxm/Mgat1tm2Jxm,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Mgat1tm2Jxm/Mgat1tm2Jxm,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008545 absent sperm flagella "mature spermatozoa lack a flagella" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Mgat1tm2Jxm/Mgat1tm2Jxm,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
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Allelic Composition: C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Mgat1tm2Jxm/Mgat1tm2Jxm,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008898 abnormal acrosome morphology "any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100]
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Allelic Composition: C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Mgat1tm2Jxm/Mgat1tm2Jxm,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Mgat1tm2Jxm/Mgat1tm2Jxm,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009231 detached acrosome "detachment or loss of adhesion of the acrosome cap from the sperm head nucleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Mgat1tm2Jxm/Mgat1tm2Jxm,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Mgat1tm2Jxm/Mgat1tm2Jxm,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009830 abnormal sperm connecting piece morphology "any structural abnormality in the segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum" [PMID:14581499]
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Allelic Composition: C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Mgat1tm2Jxm/Mgat1tm2Jxm,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009838 abnormal sperm axoneme morphology "any structural abnormality of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion" [PMID:14581499]
Show

Allelic Composition: C1galt1tm1.1Rpmc/C1galt1tm1.1Rpmc,Mgat1tm2Jxm/Mgat1tm2Jxm,Tg(Zp3-cre)1Gwh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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