ENSMUSG00000046006


Mus musculus

Features
Gene ID: ENSMUSG00000046006
  
Biological name :Gapt
  
Synonyms : Gapt / Protein GAPT / Q8CB93
  
Possible biological names infered from orthology : GRB2 binding adaptor protein, transmembrane / Q8N292
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D2.1
Gene start: 110352616
Gene end: 110357199
  
Corresponding Affymetrix probe sets: 10412078 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000053775
Ensembl peptide - ENSMUSP00000153170
NCBI entrez gene - 238875     See in Manteia.
MGI - MGI:3608341
RefSeq - XM_006517652
RefSeq - NM_177713
RefSeq - XM_006517650
RefSeq - XM_006517651
RefSeq Peptide - NP_808381
swissprot - Q8CB93
Ensembl - ENSMUSG00000046006
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GAPTENSG00000175857Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR021082  Protein GAPT


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001782 B cell homeostasis IMP
 biological_processGO:0002322 B cell proliferation involved in immune response IMP
 biological_processGO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response IMP
 biological_processGO:0042113 B cell activation IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Myt1)2Ggu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Myt1)2Ggu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Myt1)2Ggu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Myt1)2Ggu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdx1tm1Macd/Pdx1+,Tg(tetO-Myt1)2Ggu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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