ENSMUSG00000046062


Mus musculus

Features
Gene ID: ENSMUSG00000046062
  
Biological name :Ppp1r15b
  
Synonyms : Ppp1r15b / Protein phosphatase 1 regulatory subunit 15B / Q8BFW3
  
Possible biological names infered from orthology : Q5SWA1
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E4
Gene start: 133131143
Gene end: 133139783
  
Corresponding Affymetrix probe sets: 10349868 (MoGene1.0st)   1426798_a_at (Mouse Genome 430 2.0 Array)   1436366_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057062
NCBI entrez gene - 108954     See in Manteia.
MGI - MGI:2444211
RefSeq - NM_133819
RefSeq Peptide - NP_598580
swissprot - Q8BFW3
Ensembl - ENSMUSG00000046062
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp1r15bENSDARG00000068128Danio rerio
 PPP1R15BENSGALG00000000611Gallus gallus
 Q5SWA1ENSG00000158615Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR019512  Protein phosphatase 1, regulatory subunit 15B, N-terminal
 IPR019523  Protein phosphatase 1, regulatory subunit 15A/B, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006446 regulation of translational initiation IC
 biological_processGO:0006979 response to oxidative stress IMP
 biological_processGO:0006983 ER overload response IMP
 biological_processGO:0034976 response to endoplasmic reticulum stress IMP
 biological_processGO:0042542 response to hydrogen peroxide IMP
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0070262 peptidyl-serine dephosphorylation IDA
 biological_processGO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IDA
 cellular_componentGO:0000164 protein phosphatase type 1 complex IEA
 molecular_functionGO:0019888 protein phosphatase regulator activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Eif2s1tm1Rjk/Eif2s1tm1Rjk,Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic Background: involves: 129P2/OlaHsd

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0000256 echinocytosis "a state in which the red blood cells have multiple small projections appearing over the cell circumference resembling a small burr or a sea urchin" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eif2s1tm1Rjk/Eif2s1tm1Rjk,Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic Background: involves: 129P2/OlaHsd

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

Allelic Composition: Eif2s1tm1Rjk/Eif2s1+,Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Eif2s1tm1Rjk/Eif2s1tm1Rjk,Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic Background: involves: 129P2/OlaHsd

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0005642 decreased mean corpuscular hemoglobin concentration "less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif2s1tm1Rjk/Eif2s1+,Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Eif2s1tm1Rjk/Eif2s1tm1Rjk,Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic Background: involves: 129P2/OlaHsd

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

Allelic Composition: Eif2s1tm1Rjk/Eif2s1tm1Rjk,Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic Background: involves: 129P2/OlaHsd

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Eif2s1tm1Rjk/Eif2s1tm1Rjk,Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr