ENSMUSG00000046245


Mus musculus

Features
Gene ID: ENSMUSG00000046245
  
Biological name :Pilra
  
Synonyms : Paired immunoglobulin-like type 2 receptor alpha / Pilra / Q2YFS3
  
Possible biological names infered from orthology : paired immunoglobin like type 2 receptor alpha / paired immunoglobin-like type 2 receptor beta / PILRB / Q9UKJ0 / Q9UKJ1
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 137821952
Gene end: 137836281
  
Corresponding Affymetrix probe sets: 10534927 (MoGene1.0st)   1427327_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106608
Ensembl peptide - ENSMUSP00000142631
Ensembl peptide - ENSMUSP00000142391
Ensembl peptide - ENSMUSP00000050313
NCBI entrez gene - 231805     See in Manteia.
MGI - MGI:2450529
RefSeq - NM_153510
RefSeq Peptide - NP_705730
swissprot - A0A0G2JE49
swissprot - A0A0G2JDJ3
swissprot - Q2YFS3
Ensembl - ENSMUSG00000046245
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PILRAENSG00000085514Homo sapiens
 PILRBENSG00000121716Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q2YFS2 / Pilrb1 / Paired immunoglobulin-like type 2 receptor beta / PILRB* / PILRA* / Q9UKJ0* / Q9UKJ1* / paired immunoglobin-like type 2 receptor beta* / paired immunoglobin like type 2 r...ENSMUSG0000006668452
Q2YFS1 / Pilrb2 / Paired immunoglobulin-like type 2 receptor beta-2 / PILRB* / PILRA* / Q9UKJ0* / Q9UKJ1* / paired immunoglobin-like type 2 receptor beta* / paired immunoglobin like type 2...ENSMUSG0000006668251


Protein motifs (from Interpro)
Interpro ID Name
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction ISO
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042288 MHC class I protein binding IBA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pknox1tm2.1Fbla/Pknox1tm2.1Fbla,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pknox1tm2.1Fbla/Pknox1tm2.1Fbla,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pknox1tm2.1Fbla/Pknox1tm2.1Fbla,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002944 increased lactate dehydrogenase level "greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87714]
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Allelic Composition: Pknox1tm2.1Fbla/Pknox1tm2.1Fbla,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Pknox1tm2.1Fbla/Pknox1tm2.1Fbla,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pknox1tm2.1Fbla/Pknox1tm2.1Fbla,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pknox1tm2.1Fbla/Pknox1tm2.1Fbla,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pknox1tm2.1Fbla/Pknox1tm2.1Fbla,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pknox1tm2.1Fbla/Pknox1tm2.1Fbla,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pknox1tm2.1Fbla/Pknox1tm2.1Fbla,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

 MP:0012246 abnormal hepatic cord morphology "any structural anomaly of the three-dimensional arrangement formed by plates of hepatocytes, usually one cell thick, that radiates from the center of the liver lobule; hepatic laminae are highly branched, irregular structures bordered by endothelial lined vascular spaces called hepatic sinusoids" [MGI:anna]
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Allelic Composition: Pknox1tm2.1Fbla/Pknox1tm2.1Fbla,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000074491 Clec4g / Q8BNX1 / C-type lectin domain family 4 member G / Q6UXB4*  / complex / reaction
 ENSMUSG00000015094 Npdc1 / Q64322 / Neural proliferation differentiation and control protein 1 / Q9NQX5* / neural proliferation, differentiation and control 1*  / reaction / complex
 ENSMUSG00000036103 Q8K4Q8 / Colec12 / Collectin-12 / Q5KU26* / collectin subfamily member 12*  / complex / reaction
 ENSMUSG00000030329 Pianp / Q6P1B3 / PILR alpha-associated neural protein / Q8IYJ0*  / reaction / complex






 

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