ENSMUSG00000046516


Mus musculus

Features
Gene ID: ENSMUSG00000046516
  
Biological name :Cox17
  
Synonyms : Cox17 / Cytochrome c oxidase copper chaperone / P56394
  
Possible biological names infered from orthology : COX17, cytochrome c oxidase copper chaperone / Q14061
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B3
Gene start: 38346991
Gene end: 38352763
  
Corresponding Affymetrix probe sets: 10435693 (MoGene1.0st)   1434435_s_at (Mouse Genome 430 2.0 Array)   1434871_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054086
Ensembl peptide - ENSMUSP00000113430
NCBI entrez gene - 12856     See in Manteia.
MGI - MGI:1333806
RefSeq - XM_006521750
RefSeq - NM_001017429
RefSeq Peptide - NP_001017429
swissprot - P56394
swissprot - Q54AC6
Ensembl - ENSMUSG00000046516
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cox17ENSDARG00000069920Danio rerio
 COX17ENSGALG00000014981Gallus gallus
 COX17ENSG00000138495Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P56394 / Gm21987 / predicted gene 21987 / COX17* / Q14061* / COX17, cytochrome c oxidase copper chaperone*ENSMUSG00000095464100


Protein motifs (from Interpro)
Interpro ID Name
 IPR007745  Cytochrome c oxidase copper chaperone
 IPR009069  Cysteine alpha-hairpin motif superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006825 copper ion transport IBA
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0033617 mitochondrial respiratory chain complex IV assembly IBA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:1904960 positive regulation of cytochrome-c oxidase activity ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005758 mitochondrial intermembrane space IBA
 molecular_functionGO:0005507 copper ion binding IDA
 molecular_functionGO:0008047 enzyme activator activity IMP
 molecular_functionGO:0016531 copper chaperone activity ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:1903136 cuprous ion binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tbx1tm1.1Dsr/Tbx1tm1.1Dsr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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