ENSMUSG00000047379


Mus musculus

Features
Gene ID: ENSMUSG00000047379
  
Biological name :B4gat1
  
Synonyms : B4gat1 / Beta-1,4-glucuronyltransferase 1 / Q8BWP8
  
Possible biological names infered from orthology : O43505
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 5038826
Gene end: 5041134
  
Corresponding Affymetrix probe sets: 10460513 (MoGene1.0st)   1452346_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062016
NCBI entrez gene - 108902     See in Manteia.
MGI - MGI:1919680
RefSeq - NM_175383
RefSeq Peptide - NP_780592
swissprot - Q8BWP8
Ensembl - ENSMUSG00000047379
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 b4gat1ENSDARG00000077583Danio rerio
 B4GAT1ENSG00000174684Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Large2 / Q5XPT3 / LARGE xylosyl- and glucuronyltransferase 2 Xylosyltransferase LARGE2 Beta-1,3-glucuronyltransferase LARGE2 / Q8N3Y3* / LARGE xylosyl- and glucuronyltransferase 2*ENSMUSG0000004043423
Large1 / Q9Z1M7 / LARGE xylosyl- and glucuronyltransferase 1 Xylosyltransferase LARGE Beta-1,3-glucuronyltransferase LARGE / O95461* / LARGE xylosyl- and glucuronyltransferase 1*ENSMUSG0000000438323
Q3U4G3 / Xxylt1 / xyloside xylosyltransferase 1 / Q8NBI6*ENSMUSG000000474346


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IMP
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0035269 protein O-linked mannosylation IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0015020 glucuronosyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Keratan sulfate biosynthesis
O-linked glycosylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
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Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0000778 abnormal tract 
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Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: B4gat1tm1Mifu/B4gat1tm1Mifu,Gcnt1tm1Jxm/Gcnt1tm1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004272 abnormal basement membrane morphology "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220]
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Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aspatm1b(EUCOMM)Wtsi/Aspatm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Aspatm1b(EUCOMM)Wtsi/Ieg

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cxcr6tm1Lex/Cxcr6+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Cxcr6tm1Lex/Cxcr6+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: B4gat1tm1Mifu/B4gat1tm1Mifu,Gcnt1tm1Jxm/Gcnt1tm1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009417 skeletal muscle atrophy "a wasting of skeletal muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0009677 abnormal spinal cord dorsal column morphology "any structural anomaly of the wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN-10:0940780577 "Goldberg, S, Clinical Neuroanatomy Made Ridiculously Simple, 3rd edition"]
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Allelic Composition: Hoxa2tm2.1Fmr/Hoxa2tm2.1Fmr,Hoxb2tm2.2Fmr/Hoxb2tm2.2Fmr
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0009695 abnormal spinal cord ventral commissure morphology "any structural anomaly of the band of nerve fibers which cross the midline of the spinal cord ventral to the central canal and posterior grey commissure" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Slc6a3tm1(cre)Xz/Slc6a3+
Genetic Background: involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Arf4tm1b(KOMP)Wtsi/Arf4tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Arf4tm1b(KOMP)Wtsi/Ucd

 MP:0011723 ectopic neuron "appearance of a neuron or group of neurons in a region where it is not normally found" [MGI:csmith]
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Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

 MP:0020332 impaired leukocyte tethering or rolling "reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Cxcr6tm1Lex/Cxcr6+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: B4gat1tm1Mifu/B4gat1tm1Mifu,Gcnt1tm1Jxm/Gcnt1tm1Jxm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0020391 radial glial endfoot detachment "detachment of the radial glia cell endfoot from the pial basement membrane" [MGI:anna, PMID:17715063, PMID:23217742, PMID:24256719]
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Allelic Composition: B4gat1m1Ddg/B4gat1tm1(KOMP)Vlcg
Genetic Background: involves: C3H/He * C57BL/6 * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004383 Large1 / Q9Z1M7 / LARGE xylosyl- and glucuronyltransferase 1 Xylosyltransferase LARGE Beta-1,3-glucuronyltransferase LARGE / O95461* / LARGE xylosyl- and glucuronyltransferase 1*  / complex
 ENSMUSG00000040434 Large2 / Q5XPT3 / LARGE xylosyl- and glucuronyltransferase 2 Xylosyltransferase LARGE2 Beta-1,3-glucuronyltransferase LARGE2 / Q8N3Y3* / LARGE xylosyl- and glucuronyltransferase 2*  / complex






 

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