Manteia - Molecule gene

ENSMUSG00000047388

Mus musculus

Features

Gene ID:	ENSMUSG00000047388

Biological name :	Atmin

Synonyms :	Atmin / ATM interactor / Q6P9S1

Possible biological names infered from orthology :	O43313

Species:	Mus musculus

Chr. number:	8
Strand:	1
Band:	E1
Gene start:	116943393
Gene end:	116960445

Corresponding Affymetrix probe sets:	10575745 (MoGene1.0st) 1434143_at (Mouse Genome 430 2.0 Array) 1434381_at (Mouse Genome 430 2.0 Array) 1457629_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000104727 NCBI entrez gene - 234776 See in Manteia. MGI - MGI:2682328 RefSeq - XM_006530929 RefSeq - NM_177700 RefSeq - XM_006530927 RefSeq - XM_006530928 RefSeq Peptide - NP_808368 swissprot - Q6P9S1 Ensembl - ENSMUSG00000047388

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
atmin	ENSDARG00000068601	Danio rerio
ATMIN	ENSGALG00000040475	Gallus gallus
ATMIN	ENSG00000166454	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR013087	Zinc finger C2H2-type

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006974	cellular response to DNA damage stimulus	IEA
biological_process	GO:0010628	positive regulation of gene expression	IDA
biological_process	GO:0044458	motile cilium assembly	IMP
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IEA
biological_process	GO:1902857	positive regulation of non-motile cilium assembly	IMP
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0016604	nuclear body	IEA
molecular_function	GO:0003676	nucleic acid binding	IEA
molecular_function	GO:0044212	transcription regulatory region DNA binding	IDA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0070840	dynein complex binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000352	decreased cell proliferation	"less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Atmin^tm1.1Axbe/Atmin^tm1.1Axbe Genetic Background: involves: BALB/c * C57BL/6
MP:0000428	abnormal craniofacial morphology	"anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Dnah11^lrm5/Dnah11^lrm5 Genetic Background: involves: BALB/cAnN * C3H/HeH Allelic Composition: Atmin^tm1.1Axbe/Atmin^tm1.1Axbe Genetic Background: involves: BALB/c * C57BL/6
MP:0000531	right pulmonary isomerism	"bilaterally symmetric right lung pattern (or altered asymmetric patterning of the lung)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:58530]	Show Allelic Composition: Dnah11^lrm5/Dnah11^lrm5 Genetic Background: involves: BALB/cAnN * C3H/HeH
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Trp53^tm1Brn/Trp53^tm1Brn,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6
MP:0000692	small spleen	"decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0000914	exencephaly	"neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Dnah11^lrm5/Dnah11^lrm5 Genetic Background: involves: BALB/cAnN * C3H/HeH Allelic Composition: Atmin^tm1.1Axbe/Atmin^tm1.1Axbe Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh Genetic Background: C57BL/6-Atmin^tm1.1Jhh Allelic Composition: Atmin^gpg6/Atmin^gpg6 Genetic Background: C3H.C-Atmin^gpg6 Allelic Composition: Atmin^m1H/Atmin^m1H Genetic Background: C3H.C-Atmin^m1H Allelic Composition: Atmin^gpg6/Atmin^m1H Genetic Background: C3.C-Atmin^gpg6/Atmin^m1H
MP:0001181	absent lungs	"missing organs of respiration" [J:51966, J:50768]	Show Allelic Composition: Dnah11^lrm5/Dnah11^lrm5 Genetic Background: involves: BALB/cAnN * C3H/HeH Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh Genetic Background: C57BL/6-Atmin^tm1.1Jhh Allelic Composition: Atmin^m1H/Atmin^m1H Genetic Background: C3H.C-Atmin^m1H Allelic Composition: Atmin^gpg6/Atmin^m1H Genetic Background: C3.C-Atmin^gpg6/Atmin^m1H
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Edar^Dl-slk/Edar⁺ Genetic Background: Not Specified
MP:0001297	microphthalmia	"reduced average size of the eyes" [J:18048]	Show Allelic Composition: Atmin^gpg6/Atmin^gpg6 Genetic Background: C3H.C-Atmin^gpg6 Allelic Composition: Atmin^m1H/Atmin^m1H Genetic Background: C3H.C-Atmin^m1H Allelic Composition: Atmin^gpg6/Atmin^m1H Genetic Background: C3.C-Atmin^gpg6/Atmin^m1H
MP:0001363	increased anxiety-related response	"when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]	Show Allelic Composition: Edar^Dl-slk/Edar⁺ Genetic Background: Not Specified
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Edar^Dl-slk/Edar⁺ Genetic Background: Not Specified
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Dnah11^lrm5/Dnah11^lrm5 Genetic Background: involves: BALB/cAnN * C3H/HeH Allelic Composition: Atmin^gpg6/Atmin^gpg6 Genetic Background: C3H.C-Atmin^gpg6 Allelic Composition: Atmin^m1H/Atmin^m1H Genetic Background: C3H.C-Atmin^m1H Allelic Composition: Atmin^gpg6/Atmin^m1H Genetic Background: C3.C-Atmin^gpg6/Atmin^m1H
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Foxp3^sf/Y Genetic Background: B6.Cg-Foxp3^sf
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Edar^Dl-slk/Edar⁺ Genetic Background: Not Specified
MP:0002092	abnormal eye morphology	"abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dnah11^lrm5/Dnah11^lrm5 Genetic Background: involves: BALB/cAnN * C3H/HeH
MP:0002144	abnormal B lymphocyte development	"atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0002166	altered tumor susceptibility/resistance	"greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺,Tg(IghMyc)22Bri/0 Genetic Background: B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh Tg(IghMyc)22Bri
MP:0002229	CNS neurodegeneration	"a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Edar^Dl-slk/Edar⁺ Genetic Background: Not Specified
MP:0002459	abnormal B cell physiology	"abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rp1^tm2.1Eap/Rp1^tm2.1Eap,Tg(Rp1)L2Eap/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002639	micrognathia	"abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Dnah11^lrm5/Dnah11^lrm5 Genetic Background: involves: BALB/cAnN * C3H/HeH
MP:0002766	situs inversus	"lateral transposition of the viscera of the thorax and abdomen, sometimes incomplete" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Dnah11^lrm5/Dnah11^lrm5 Genetic Background: involves: BALB/cAnN * C3H/HeH
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Rp1^tm2.1Eap/Rp1^tm2.1Eap,Tg(Rp1)L2Eap/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002989	small kidney	"reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dnah11^lrm5/Dnah11^lrm5 Genetic Background: involves: BALB/cAnN * C3H/HeH
MP:0003054	spina bifida	"common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Dnah11^lrm5/Dnah11^lrm5 Genetic Background: involves: BALB/cAnN * C3H/HeH
MP:0003115	abnormal respiratory system development	"aberrant differentiation of pulmonary tissues" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh Genetic Background: C57BL/6-Atmin^tm1.1Jhh
MP:0003132	increased number of pre-B cells	"greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Bcl2l11^tm1.1Ast/Bcl2l11^tm1.1Ast,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6
MP:0003178	left pulmonary isomerism	"bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051]	Show Allelic Composition: Dnah11^lrm5/Dnah11^lrm5 Genetic Background: involves: BALB/cAnN * C3H/HeH Allelic Composition: Atmin^gpg6/Atmin^gpg6 Genetic Background: C3H.C-Atmin^gpg6 Allelic Composition: Atmin^m1H/Atmin^m1H Genetic Background: C3H.C-Atmin^m1H Allelic Composition: Atmin^gpg6/Atmin^m1H Genetic Background: C3.C-Atmin^gpg6/Atmin^m1H
MP:0003244	loss of dopaminergic neurons	"loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]	Show Allelic Composition: Edar^Dl-slk/Edar⁺ Genetic Background: Not Specified
MP:0003354	astrocytosis	"a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Edar^Dl-slk/Edar⁺ Genetic Background: Not Specified
MP:0003641	small lung	"reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]	Show Allelic Composition: Atmin^gpg6/Atmin^gpg6 Genetic Background: C3H.C-Atmin^gpg6 Allelic Composition: Atmin^m1H/Atmin^m1H Genetic Background: C3H.C-Atmin^m1H Allelic Composition: Atmin^gpg6/Atmin^m1H Genetic Background: C3.C-Atmin^gpg6/Atmin^m1H
MP:0004131	abnormal embryonic ciliary morphology	"any structural malformation of the earliest cilia of the mouse embryo found on the cells of the embryonic node" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Dnah11^lrm5/Dnah11^lrm5 Genetic Background: involves: BALB/cAnN * C3H/HeH
MP:0004157	interrupted aortic arch	"complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Dnah11^lrm5/Dnah11^lrm5 Genetic Background: involves: BALB/cAnN * C3H/HeH Allelic Composition: Atmin^gpg6/Atmin^gpg6 Genetic Background: C3H.C-Atmin^gpg6
MP:0004158	right aortic arch	"the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Dnah11^lrm5/Dnah11^lrm5 Genetic Background: involves: BALB/cAnN * C3H/HeH
MP:0004201	fetal growth retardation	"slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh Genetic Background: C57BL/6-Atmin^tm1.1Jhh
MP:0004936	abnormal ureteric bud branching morphogenesis	"partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dnah11^lrm5/Dnah11^lrm5 Genetic Background: involves: BALB/cAnN * C3H/HeH
MP:0004952	increased spleen weight	"greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Bcl2l11^tm1.1Ast/Bcl2l11^tm1.1Ast,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6
MP:0004953	decreased spleen weight	"reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0004967	abnormal kidney epithelium morphology	"any structural anomaly of the cellular avascular layer of the kidney luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dnah11^lrm5/Dnah11^lrm5 Genetic Background: involves: BALB/cAnN * C3H/HeH
MP:0005014	increased B cell number	"greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Bcl2l11^tm1.1Ast/Bcl2l11^tm1.1Ast,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6
MP:0005016	decreased lymphocyte number	"fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rp1^tm2.1Eap/Rp1^tm2.1Eap,Tg(Rp1)L2Eap/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rp1^tm2.1Eap/Rp1^tm2.1Eap,Tg(Rp1)L2Eap/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Trp53^tm1Brn/Trp53^tm1Brn,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺,Tg(IghMyc)22Bri/0 Genetic Background: B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh Tg(IghMyc)22Bri
MP:0005262	coloboma	"anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Atmin^gpg6/Atmin^gpg6 Genetic Background: C3H.C-Atmin^gpg6 Allelic Composition: Atmin^m1H/Atmin^m1H Genetic Background: C3H.C-Atmin^m1H Allelic Composition: Atmin^gpg6/Atmin^m1H Genetic Background: C3.C-Atmin^gpg6/Atmin^m1H
MP:0005621	abnormal cell physiology	"aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Atmin^tm1.1Axbe/Atmin^tm1.1Axbe Genetic Background: involves: BALB/c * C57BL/6
MP:0006065	abnormal heart position	"the heart is displaced from the normal left-sided position and/or orientation" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh Genetic Background: C57BL/6-Atmin^tm1.1Jhh
MP:0006126	abnormal outflow tract development	"anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Atmin^gpg6/Atmin^gpg6 Genetic Background: C3H.C-Atmin^gpg6
MP:0008008	early cellular replicative senescence	"increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atmin^tm1.1Axbe/Atmin^tm1.1Axbe Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh Genetic Background: C57BL/6-Atmin^tm1.1Jhh
MP:0008209	decreased pre-B cell number	"reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rp1^tm2.1Eap/Rp1^tm2.1Eap,Tg(Rp1)L2Eap/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0008211	decreased mature B cell number	"reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]	Show Allelic Composition: Rp1^tm2.1Eap/Rp1^tm2.1Eap,Tg(Rp1)L2Eap/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6
MP:0008214	increased immature B cell number	"greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Bcl2l11^tm1.1Ast/Bcl2l11^tm1.1Ast,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129S1/Sv * BALB/c * C57BL/6
MP:0008215	decreased immature B cell number	"reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Atmin^tm1.2Jhh/Atmin^tm1.2Jhh,Trp53^tm1Brn/Trp53^tm1Brn,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺,Tg(IghMyc)22Bri/0 Genetic Background: B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh Tg(IghMyc)22Bri
MP:0008404	increased cellular sensitivity to methylmethanesulfonate	"greater incidence of cell death following exposure to methylmethanesulfonate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh Genetic Background: C57BL/6-Atmin^tm1.1Jhh
MP:0008406	increased cellular sensitivity to hydrogen peroxide	"greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh Genetic Background: C57BL/6-Atmin^tm1.1Jhh
MP:0008495	decreased IgG1 level	"less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh
MP:0008782	increased B cell apoptosis	"increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺,Tg(IghMyc)22Bri/0 Genetic Background: B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh Tg(IghMyc)22Bri
MP:0008948	decreased neuron number	"fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]	Show Allelic Composition: Edar^Dl-slk/Edar⁺ Genetic Background: Not Specified
MP:0009431	decreased fetal weight	"reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh Genetic Background: C57BL/6-Atmin^tm1.1Jhh
MP:0009796	abnormal base-excision repair	"any anomaly in the process whereby an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate; the small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase" [GO:0006284]	Show Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh Genetic Background: C57BL/6-Atmin^tm1.1Jhh
MP:0009828	delayed tumor appearance	"later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺,Tg(IghMyc)22Bri/0 Genetic Background: B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh Tg(IghMyc)22Bri
MP:0010268	decreased lymphoma incidence	"less than the expected number of neoplasms derived from lymphoid tissue in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺,Tg(IghMyc)22Bri/0 Genetic Background: B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh Tg(IghMyc)22Bri
MP:0010454	abnormal truncus arteriosis septation	"anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dnah11^lrm5/Dnah11^lrm5 Genetic Background: involves: BALB/cAnN * C3H/HeH
MP:0010885	absent trachea	"absence of the tube descending from the larynx and branching into the right and left main bronchi" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh Genetic Background: C57BL/6-Atmin^tm1.1Jhh
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Atmin^tm1.1Axbe/Atmin^tm1.1Axbe Genetic Background: involves: BALB/c * C57BL/6 Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh Genetic Background: C57BL/6-Atmin^tm1.1Jhh
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Trp53^tm1.1Brn/Trp53^tm1.1Brn Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011998	decreased embryonic cilium length	"reduced length of the cilia of the mouse embryo found on the cells of the embryonic node" [MGI:csmith]	Show Allelic Composition: Atmin^gpg6/Atmin^gpg6 Genetic Background: C3H.C-Atmin^gpg6
MP:0012431	increased lymphoma incidence	"greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]	Show Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh,Cd79a^tm1(cre)Reth/Cd79a⁺,Tg(IghMyc)22Bri/0 Genetic Background: B6.Cg-Cd79a^tm1(Cre)Reth Atmin^tm1.1Jhh Tg(IghMyc)22Bri
MP:0013203	abnormal primary cilium morphology	"any structural anomaly of a cilium found on many different cell types that is typically present in a single copy per cell; a primary cilium may have a variable array of axonemal microtubules and may or may not contain molecular motors" [GO:0072372]	Show Allelic Composition: Atmin^gpg6/Atmin^gpg6 Genetic Background: C3H.C-Atmin^gpg6
MP:0013213	abnormal embryonic neuroepithelium primary cilium morphology	"any structural anomaly of the primary non-motile microtubule-based structures of the embryonic neuroepithelium which are typically short and straight, project apically into the neural tube lumen, and play an essential role in Sonic hedgehog (Shh) signalling and neural tube patterning " [PMID:23351466]	Show Allelic Composition: Atmin^gpg6/Atmin^gpg6 Genetic Background: C3H.C-Atmin^gpg6
MP:0013496	abnormal trachea development	"aberrant formation or incomplete differentiation of the tube descending from the larynx and branching into the right and left main bronchi" [MGI:Anna]	Show Allelic Composition: Atmin^tm1.1Jhh/Atmin^tm1.1Jhh Genetic Background: C57BL/6-Atmin^tm1.1Jhh
MP:0030169	thick upper lip	"upper lips having an abundance and often an excess of soft tissue" [MGI:anna]	Show Allelic Composition: Atmin^gpg6/Atmin^gpg6 Genetic Background: C3H.C-Atmin^gpg6 Allelic Composition: Atmin^m1H/Atmin^m1H Genetic Background: C3H.C-Atmin^m1H Allelic Composition: Atmin^gpg6/Atmin^m1H Genetic Background: C3.C-Atmin^gpg6/Atmin^m1H

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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