ENSMUSG00000047654


Mus musculus

Features
Gene ID: ENSMUSG00000047654
  
Biological name :Tssk6
  
Synonyms : Q925K9 / Testis-specific serine/threonine-protein kinase 6 / Tssk6
  
Possible biological names infered from orthology : Q9BXA6 / testis specific serine kinase 6
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.3
Gene start: 69902184
Gene end: 69903518
  
Corresponding Affymetrix probe sets: 10572251 (MoGene1.0st)   1418956_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062783
NCBI entrez gene - 83984     See in Manteia.
MGI - MGI:2148775
RefSeq - NM_032004
RefSeq Peptide - NP_114393
swissprot - Q925K9
Ensembl - ENSMUSG00000047654
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tssk6ENSDARG00000017994Danio rerio
 TSSK6ENSG00000178093Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tssk3 / Q9D2E1 / Testis-specific serine/threonine-protein kinase 3 / Q96PN8* / testis specific serine kinase 3*ENSMUSG0000000041147
Tssk2 / O54863 / Testis-specific serine/threonine-protein kinase 2 / Q96PF2* / testis specific serine kinase 2*ENSMUSG0000004552146
Tssk1 / Q61241 / Testis-specific serine/threonine-protein kinase 1 / TSSK1B* / Q9BXA7* / testis specific serine kinase 1B*ENSMUSG0000004156646
Tssk4 / Q9D411 / testis-specific serine kinase 4 / Q6SA08*ENSMUSG0000000759138
Tssk5 / Q8C1R0 / Testis-specific serine/threonine-protein kinase 5 ENSMUSG0000006079437


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035092 sperm chromatin condensation IMP
 biological_processGO:0035556 intracellular signal transduction IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Sox9tm1.1Gsr/Sox9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Sox9tm1.1Gsr/Sox9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox9tm1.1Gsr/Sox9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Sox9tm1.1Gsr/Sox9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tssk6tm1Grj/Tssk6+
Genetic Background: involves: 129 * C57BL/6

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox9tm1.1Gsr/Sox9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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