ENSMUSG00000047773


Mus musculus

Features
Gene ID: ENSMUSG00000047773
  
Biological name :Ankfn1
  
Synonyms : Ankfn1 / ankyrin-repeat and fibronectin type III domain containing 1
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: C
Gene start: 89390223
Gene end: 89777653
  
Corresponding Affymetrix probe sets: 10389754 (MoGene1.0st)   10389759 (MoGene1.0st)   1432803_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049776
Ensembl peptide - ENSMUSP00000132133
Ensembl peptide - ENSMUSP00000146500
Ensembl peptide - ENSMUSP00000146987
Ensembl peptide - ENSMUSP00000121290
NCBI entrez gene - 382543     See in Manteia.
MGI - MGI:2686021
RefSeq - XM_017314636
RefSeq - NM_001327810
RefSeq - NM_172534
RefSeq Peptide - NP_001314739
RefSeq Peptide - NP_766122
swissprot - A0A140LHQ2
swissprot - A0A140LIW7
swissprot - F6X7B3
swissprot - F6RWQ6
swissprot - Q8CDJ6
Ensembl - ENSMUSG00000047773
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000003110Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR020683  Ankyrin repeat-containing domain
 IPR036116  Fibronectin type III superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IMP
 biological_processGO:0045475 locomotor rhythm IMP
 biological_processGO:0050957 equilibrioception IMP
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Scn8a4J/Scn8a4J
Genetic Background: C57BL/6J-Scn8a4J/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Scn8a4J/Scn8a4J
Genetic Background: C57BL/6J-Scn8a4J/J

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Scn8a4J/Scn8a4J
Genetic Background: C57BL/6J-Scn8a4J/J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Scn8a4J/Scn8a4J
Genetic Background: C57BL/6J-Scn8a4J/J

 MP:0001410 head bobbing "compulsive up and down movement of the head" [J:17123]
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Allelic Composition: Scn8a4J/Scn8a4J
Genetic Background: C57BL/6J-Scn8a4J/J

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Scn8a4J/Scn8a4J
Genetic Background: C57BL/6J-Scn8a4J/J

 MP:0004742 abnormal vestibular system physiology "any functional anomaly of the sensory system responsible for the sense of head position and movement of the body through space; such anomalies may include impaired balance, dizziness, poor regulation of postural muscle tone and inability to detect quick movements of the head " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn8a4J/Scn8a4J
Genetic Background: C57BL/6J-Scn8a4J/J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn8a4J/Scn8a4J
Genetic Background: C57BL/6J-Scn8a4J/J

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Scn8a4J/Scn8a4J
Genetic Background: C57BL/6J-Scn8a4J/J

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn8a4J/Scn8a4J
Genetic Background: C57BL/6J-Scn8a4J/J

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Scn8a4J/Scn8a4J
Genetic Background: C57BL/6J-Scn8a4J/J

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
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Allelic Composition: Scn8a4J/Scn8a4J
Genetic Background: C57BL/6J-Scn8a4J/J

 MP:0020468 abnormal circadian behavior period "any change in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
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Allelic Composition: Scn8a4J/Scn8a4J
Genetic Background: C57BL/6J-Scn8a4J/J

 MP:0020470 shortened circadian behavior period "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
Show

Allelic Composition: Scn8a4J/Scn8a4J
Genetic Background: C57BL/6J-Scn8a4J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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