ENSMUSG00000047798


Mus musculus

Features
Gene ID: ENSMUSG00000047798
  
Biological name :Cd300lf
  
Synonyms : Cd300lf / Mus musculus CD300 molecule like family member F (Cd300lf), transcript variant 3, mRNA. / Q6SJQ7
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 115116214
Gene end: 115133992
  
Corresponding Affymetrix probe sets: 10392845 (MoGene1.0st)   1427994_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102172
Ensembl peptide - ENSMUSP00000053983
Ensembl peptide - ENSMUSP00000102171
NCBI entrez gene - 246746     See in Manteia.
MGI - MGI:2442359
RefSeq - XM_017314555
RefSeq - NM_001347648
RefSeq - NM_145634
RefSeq - XM_011249022
RefSeq - XM_011249023
RefSeq - XM_017314553
RefSeq - XM_017314554
RefSeq - NM_001169153
RefSeq Peptide - NP_663609
RefSeq Peptide - NP_001162624
RefSeq Peptide - NP_001334577
swissprot - A2A6Z2
swissprot - Q6SJQ7
swissprot - A0A1C9ZQ14
Ensembl - ENSMUSG00000047798
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD300LGENSGALG00000007713Gallus gallus
 CD300L-S1ENSGALG00000019755Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8VCH2 / Cd300ld / CMRF35-like molecule 5 ENSMUSG0000003464139
Q6SJQ5 / Cd300ld3 / CMRF35-like molecule 3 ENSMUSG0000006960738
Cd300ld2 / CD300 molecule like family member D2ENSMUSG0000008975338
Cd300ld4 / CD300 molecule like family member D4ENSMUSG0000006960938
Cd300ld5 / CD300 molecule like family member D5ENSMUSG0000008972238
Cd300lb / Mus musculus CD300 molecule like family member B (Cd300lb), transcript variant 2, mRNA. / A8K4G0* / CD300 molecule like family member b*ENSMUSG0000006319323
Cd300a / Q6SJQ0 / Mus musculus CD300A molecule (Cd300a), transcript variant 2, mRNA. / Q08708* / Q9UGN4* / CD300C* / CD300c molecule* / CD300a molecule*ENSMUSG0000003465223
Q1ERP8 / Cd300lg / CMRF35-like molecule 9 / Q6UXG3* / CD300 molecule like family member g*ENSMUSG0000001730920
Cd300e / Q8K249 / CMRF35-like molecule 2 / Q496F6* / CD300e molecule*ENSMUSG0000004849820
Cd300c / CMRF35-like molecule 6 / Q9UGN4* / Q08708* / CD300A* / CD300c molecule* / CD300a molecule*ENSMUSG0000005872819
Q7TSN2 / Cd300c2 / CD300C molecule 2 / Q9UGN4* / CD300C* / Q08708* / CD300A* / CD300c molecule* / CD300a molecule*ENSMUSG0000004481118


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0030316 osteoclast differentiation IDA
 biological_processGO:0033004 negative regulation of mast cell activation ISO
 biological_processGO:0034125 negative regulation of MyD88-dependent toll-like receptor signaling pathway ISS
 biological_processGO:0035666 TRIF-dependent toll-like receptor signaling pathway ISO
 biological_processGO:0035772 interleukin-13-mediated signaling pathway IMP
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:1902216 positive regulation of interleukin-4-mediated signaling pathway IMP
 biological_processGO:2000426 negative regulation of apoptotic cell clearance IMP
 biological_processGO:2000427 positive regulation of apoptotic cell clearance IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001618 virus receptor activity IMP
 molecular_functionGO:0001786 phosphatidylserine binding IDA
 molecular_functionGO:0005136 interleukin-4 receptor binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0097001 ceramide binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0002405 respiratory system inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: a/a,Mregdsu/Mregdsu,Hps6ru/Hps6ru
Genetic Background: involves: C57BL/6J

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: a/a,Mregdsu/Mregdsu,Hps6ru/Hps6ru
Genetic Background: involves: C57BL/6J

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: a/a,Mregdsu/Mregdsu,Hps6ru/Hps6ru
Genetic Background: involves: C57BL/6J

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: a/a,Mregdsu/Mregdsu,Hps6ru/Hps6ru
Genetic Background: involves: C57BL/6J

 MP:0008654 increased interleukin-1 alpha secretion "increase in the production or release of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active" [MESH:D12.644.276.374.465.501.300]
Show

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Smim3tm1Anjm/Smim3+,Cd74tm1Anjm/Cd74+,Lmo2tm2(cre)Thr/Lmo2+,Trp53tm1Brd/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
Show

Allelic Composition: a/a,Mregdsu/Mregdsu,Hps6ru/Hps6ru
Genetic Background: involves: C57BL/6J

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: a/a,Mregdsu/Mregdsu,Hps6ru/Hps6ru
Genetic Background: involves: C57BL/6J

 MP:0008702 increased interleukin-5 secretion "increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
Show

Allelic Composition: a/a,Mregdsu/Mregdsu,Hps6ru/Hps6ru
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr