ENSMUSG00000047945


Mus musculus

Features
Gene ID: ENSMUSG00000047945
  
Biological name :Marcksl1
  
Synonyms : Marcksl1 / MARCKS-related protein / P28667
  
Possible biological names infered from orthology : MARCKS like 1 / P49006
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 129513581
Gene end: 129515985
  
Corresponding Affymetrix probe sets: 10508465 (MoGene1.0st)   1415922_s_at (Mouse Genome 430 2.0 Array)   1435415_x_at (Mouse Genome 430 2.0 Array)   1435627_x_at (Mouse Genome 430 2.0 Array)   1437226_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000055637
NCBI entrez gene - 17357     See in Manteia.
MGI - MGI:97143
RefSeq - NM_010807
RefSeq Peptide - NP_034937
swissprot - P28667
Ensembl - ENSMUSG00000047945
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 marcksl1aENSDARG00000039034Danio rerio
 marcksl1bENSDARG00000035715Danio rerio
 MARCKSL1ENSGALG00000032335Gallus gallus
 P49006ENSG00000175130Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002101  Myristoylated alanine-rich C-kinase substrate MARCKS


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Chil1tm1Eli/Chil1tm1Eli,Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Chil1tm1Eli/Chil1tm1Eli,Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chil1tm1Eli/Chil1tm1Eli,Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Chil1tm1Eli/Chil1tm1Eli,Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chil1tm1Eli/Chil1tm1Eli,Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Marcksl1tm1Stl/Marcksl1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Chil1tm1Eli/Chil1tm1Eli,Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chil1tm1Eli/Chil1tm1Eli,Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Chil1tm1Eli/Chil1tm1Eli,Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Marcksl1tm1Stl/Marcksl1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa
Genetic Background: B6.129-Mfge8tm1Osa

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Chil1tm1Eli/Chil1tm1Eli,Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Chil1tm1Eli/Chil1tm1Eli,Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Chil1tm1Eli/Chil1tm1Eli,Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
Show

Allelic Composition: Chil1tm1Eli/Chil1tm1Eli,Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
Show

Allelic Composition: Chil1tm1Eli/Chil1tm1Eli,Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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