ENSMUSG00000048000


Mus musculus

Features
Gene ID: ENSMUSG00000048000
  
Biological name :Gigyf2
  
Synonyms : Gigyf2 / GRB10-interacting GYF protein 2 / Q6Y7W8
  
Possible biological names infered from orthology : Q6Y7W6
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C5
Gene start: 87326998
Gene end: 87450796
  
Corresponding Affymetrix probe sets: 10348201 (MoGene1.0st)   1439837_at (Mouse Genome 430 2.0 Array)   1451397_at (Mouse Genome 430 2.0 Array)   1451856_at (Mouse Genome 430 2.0 Array)   1457472_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134677
Ensembl peptide - ENSMUSP00000134620
Ensembl peptide - ENSMUSP00000134660
Ensembl peptide - ENSMUSP00000027475
Ensembl peptide - ENSMUSP00000129046
Ensembl peptide - ENSMUSP00000133327
Ensembl peptide - ENSMUSP00000133392
Ensembl peptide - ENSMUSP00000133416
Ensembl peptide - ENSMUSP00000133666
Ensembl peptide - ENSMUSP00000134077
Ensembl peptide - ENSMUSP00000134086
Ensembl peptide - ENSMUSP00000134193
Ensembl peptide - ENSMUSP00000134553
NCBI entrez gene - 227331     See in Manteia.
MGI - MGI:2138584
RefSeq - XM_017320347
RefSeq - NM_001110212
RefSeq - NM_146112
RefSeq - XM_006529464
RefSeq - XM_006529465
RefSeq - XM_006529466
RefSeq - XM_006529467
RefSeq - XM_006529468
RefSeq - XM_006529469
RefSeq - XM_006529470
RefSeq Peptide - NP_666224
RefSeq Peptide - NP_001103682
swissprot - E9Q2M5
swissprot - G3UWT6
swissprot - G3UXF2
swissprot - G3UYG6
swissprot - G3UYH4
swissprot - G3UYR9
swissprot - G3UZM3
swissprot - G3UZS9
swissprot - G3UZW5
swissprot - G3UWR2
swissprot - G3UZX7
swissprot - Q6Y7W8
Ensembl - ENSMUSG00000048000
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gigyf2ENSDARG00000009735Danio rerio
 GIGYF2ENSGALG00000038730Gallus gallus
 GIGYF2ENSG00000204120Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gigyf1 / Q99MR1 / GRB10-interacting GYF protein 1 / O75420*ENSMUSG0000002971440


Protein motifs (from Interpro)
Interpro ID Name
 IPR003169  GYF domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR035445  GYF-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007631 feeding behavior IMP
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0016441 posttranscriptional gene silencing ISO
 biological_processGO:0017148 negative regulation of translation ISO
 biological_processGO:0021522 spinal cord motor neuron differentiation IMP
 biological_processGO:0031571 mitotic G1 DNA damage checkpoint IMP
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0044267 cellular protein metabolic process IMP
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway ISO
 biological_processGO:0048873 homeostasis of number of cells within a tissue IMP
 biological_processGO:0050881 musculoskeletal movement IMP
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 biological_processGO:0061157 mRNA destabilization ISO
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0010494 cytoplasmic stress granule ISO
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043204 perikaryon IDA
 cellular_componentGO:1990635 proximal dendrite IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0070064 proline-rich region binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0008493 alpha-synuclein inclusion body "formation of aggregates of the alpha-synuclein protein in neural and glial tissue; often seen in neurodegenerative disorders such as Parkinson s disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0008946 abnormal neuron number "anomaly in the number of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Prdm1tm1.1Clme/Prdm1tm2.1Liz
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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