ENSMUSG00000048217


Mus musculus

Features
Gene ID: ENSMUSG00000048217
  
Biological name :Nags
  
Synonyms : N-acetylglutamate synthase, mitochondrial N-acetylglutamate synthase long form N-acetylglutamate synthase short form N-acetylglutamate synthase conserved domain form / Nags / Q8R4H7
  
Possible biological names infered from orthology : N-acetylglutamate synthase / Q8N159
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 102145513
Gene end: 102149477
  
Corresponding Affymetrix probe sets: 10381528 (MoGene1.0st)   1425230_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050258
NCBI entrez gene - 217214     See in Manteia.
MGI - MGI:2387600
RefSeq - NM_145829
RefSeq Peptide - NP_665828
swissprot - Q8R4H7
Ensembl - ENSMUSG00000048217
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nagsENSDARG00000077193Danio rerio
 NAGSENSG00000161653Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006855  Vertebrate-like NAGS Gcn5-related N-acetyltransferase (GNAT) domain
 IPR011243  N-acetylglutamate synthase, animal
 IPR016181  Acyl-CoA N-acyltransferase
 IPR036393  Acetylglutamate kinase-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000050 urea cycle IEA
 biological_processGO:0006526 arginine biosynthetic process IBA
 biological_processGO:0006536 glutamate metabolic process IDA
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005759 mitochondrial matrix IEA
 molecular_functionGO:0004042 acetyl-CoA:L-glutamate N-acetyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0034618 arginine binding IBA
 molecular_functionGO:0103045 methione N-acyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Urea cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr1h3tm1.1Djm/Nr1h3tm1.1Djm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr1h3tm1.1Djm/Nr1h3tm1.1Djm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr1h3tm1.1Djm/Nr1h3tm1.1Djm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA

 MP:0005309 increased circulating ammonia level "significantly elevated levels of ammonia or its compounds in blood; often associated with liver failure and hepatic encephalopathy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83263]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr1h3tm1.1Djm/Nr1h3tm1.1Djm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr1h3tm1.1Djm/Nr1h3tm1.1Djm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr1h3tm1.1Djm/Nr1h3tm1.1Djm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Nr1h3tm1.1Djm/Nr1h3tm1.1Djm,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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