ENSMUSG00000048486


Mus musculus

Features
Gene ID: ENSMUSG00000048486
  
Biological name :Fitm2
  
Synonyms : Fat storage-inducing transmembrane protein 2 / Fitm2 / P59266
  
Possible biological names infered from orthology : Q8N6M3
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H3
Gene start: 163466379
Gene end: 163472629
  
Corresponding Affymetrix probe sets: 10489368 (MoGene1.0st)   1454935_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105045
NCBI entrez gene - 228859     See in Manteia.
MGI - MGI:2444508
RefSeq - NM_173397
RefSeq Peptide - NP_775573
swissprot - P59266
Ensembl - ENSMUSG00000048486
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fitm2ENSDARG00000034568Danio rerio
 FITM2ENSGALG00000026285Gallus gallus
 FITM2ENSG00000197296Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fitm1 / Q91V79 / Fat storage-inducing transmembrane protein 1 / A5D6W6*ENSMUSG0000002221531


Protein motifs (from Interpro)
Interpro ID Name
 IPR019388  Fat storage-inducing transmembrane protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization IEA
 biological_processGO:0008654 phospholipid biosynthetic process IBA
 biological_processGO:0010866 regulation of triglyceride biosynthetic process IMP
 biological_processGO:0010890 positive regulation of sequestering of triglyceride IDA
 biological_processGO:0019915 lipid storage IEA
 biological_processGO:0022604 regulation of cell morphogenesis IEA
 biological_processGO:0030730 sequestering of triglyceride IMP
 biological_processGO:0034389 lipid particle organization IMP
 biological_processGO:0035356 cellular triglyceride homeostasis IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IDA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Lipid particle organization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Ntrk3tm3.1(cre/ERT2)Ddg/Ntrk3tm3.1(cre/ERT2)Ddg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgf15tm1.1(KOMP)Vlcg/Fgf15tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgf15tm1.1(KOMP)Vlcg/Ucd

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Ntrk3tm3.1(cre/ERT2)Ddg/Ntrk3tm3.1(cre/ERT2)Ddg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Fitm2tm1.1Dls/Fitm2tm1.1Dls,Lepob/Lepob,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fitm2tm1.1Dls/Fitm2tm1.1Dls,Lepob/Lepob,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk3tm3.1(cre/ERT2)Ddg/Ntrk3tm3.1(cre/ERT2)Ddg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk3tm3.1(cre/ERT2)Ddg/Ntrk3tm3.1(cre/ERT2)Ddg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002970 abnormal white fat morphology "structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk3tm3.1(cre/ERT2)Ddg/Ntrk3tm3.1(cre/ERT2)Ddg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk3tm3.1(cre/ERT2)Ddg/Ntrk3tm3.1(cre/ERT2)Ddg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgf15tm1.1(KOMP)Vlcg/Fgf15tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fgf15tm1.1(KOMP)Vlcg/Ucd

 MP:0005280 abnormal fatty acid level "anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ntrk3tm3.1(cre/ERT2)Ddg/Ntrk3tm3.1(cre/ERT2)Ddg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk3tm3.1(cre/ERT2)Ddg/Ntrk3tm3.1(cre/ERT2)Ddg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk3tm3.1(cre/ERT2)Ddg/Ntrk3tm3.1(cre/ERT2)Ddg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Ntrk3tm3.1(cre/ERT2)Ddg/Ntrk3tm3.1(cre/ERT2)Ddg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fitm2tm1.1Dls/Fitm2tm1.1Dls,Lepob/Lepob,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009116 abnormal brown fat cell morphology "any structural anomaly of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals; brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation; brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria" [CL:0000449, GO:0050873, MESH:A.10.165.114.322]
Show

Allelic Composition: Ntrk3tm3.1(cre/ERT2)Ddg/Ntrk3tm3.1(cre/ERT2)Ddg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009117 abnormal white fat cell morphology "any structural anomaly of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500]
Show

Allelic Composition: Ntrk3tm3.1(cre/ERT2)Ddg/Ntrk3tm3.1(cre/ERT2)Ddg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009124 increased brown fat cell lipid droplet size "increase in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk3tm3.1(cre/ERT2)Ddg/Ntrk3tm3.1(cre/ERT2)Ddg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009137 decreased brown fat lipid droplet number "reduction in the number of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk3tm3.1(cre/ERT2)Ddg/Ntrk3tm3.1(cre/ERT2)Ddg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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