ENSMUSG00000048707


Mus musculus

Features
Gene ID: ENSMUSG00000048707
  
Biological name :Tprn
  
Synonyms : A2AI08 / Taperin / Tprn
  
Possible biological names infered from orthology : Q4KMQ1
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 25262618
Gene end: 25269885
  
Corresponding Affymetrix probe sets: 10469957 (MoGene1.0st)   1426809_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109975
NCBI entrez gene - 97031     See in Manteia.
MGI - MGI:2139535
RefSeq - NM_175286
RefSeq Peptide - NP_780495
swissprot - A2AI08
Ensembl - ENSMUSG00000048707
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tprnENSDARG00000101102Danio rerio
 ENSGALG00000042421Gallus gallus
 TPRNENSG00000176058Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BQ30 / Ppp1r18 / Phostensin / Q6NYC8* / protein phosphatase 1 regulatory subunit 18*ENSMUSG0000003459517


Protein motifs (from Interpro)
Interpro ID Name
 IPR025903  Phostensin/Taperin N-terminal domain
 IPR025907  Phostensin/Taperin PP1-binding domain
 IPR026671  Phostensin/Taperin
 IPR033359  Taperin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007605 sensory perception of sound ISS
 cellular_componentGO:0032420 stereocilium IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0019902 phosphatase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0004529 decreased outer hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0004534 decreased inner hair cell stereocilia number "decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0004749 nonsyndromic hearing loss "a form of progressive hearing loss that is not associated with visible abnormalities of the external ear or other signs and symptoms; the vast majority of hereditary hearing loss is nonsyndromic and can be associated with abnormalities of the middle ear and/or inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Tprnem1Pghu/Tprnem1Pghu
Genetic Background: B6.Cg-Tprnem1Pghu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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