ENSMUSG00000048782


Mus musculus

Features
Gene ID: ENSMUSG00000048782
  
Biological name :Insc
  
Synonyms : Insc / INSC, spindle orientation adaptor protein
  
Possible biological names infered from orthology : Q1MX18
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F1
Gene start: 114743694
Gene end: 114850383
  
Corresponding Affymetrix probe sets: 10556553 (MoGene1.0st)   1453259_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117296
Ensembl peptide - ENSMUSP00000145636
Ensembl peptide - ENSMUSP00000129505
Ensembl peptide - ENSMUSP00000125061
Ensembl peptide - ENSMUSP00000119459
Ensembl peptide - ENSMUSP00000112682
NCBI entrez gene - 233752     See in Manteia.
MGI - MGI:1917942
RefSeq - XM_006507664
RefSeq - NM_173767
RefSeq - XM_006507659
RefSeq - XM_006507662
RefSeq - XM_006507663
RefSeq Peptide - NP_776128
swissprot - E0CXR9
swissprot - D3Z267
swissprot - A0A0U1RNN4
swissprot - G3UW77
swissprot - D3Z5D7
Ensembl - ENSMUSG00000048782
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 INSCENSGALG00000032558Gallus gallus
 INSCENSG00000188487Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR031938  Protein inscuteable homologue, LGN-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0031647 regulation of protein stability IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030674 protein binding, bridging IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Ccne1tm3.1Pisc/Ccne1tm3.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Ccne1tm3.1Pisc/Ccne1tm3.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccne1tm3.1Pisc/Ccne1tm3.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Ccne1tm3.1Pisc/Ccne1tm3.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Rag2tm1Fwa/Rag2tm1Fwa,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Ccne1tm3.1Pisc/Ccne1tm3.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0004277 abnormal lateral ganglionic eminence morphology "any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Ccne1tm3.1Pisc/Ccne1tm3.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Rag2tm1Fwa/Rag2tm1Fwa,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccne1tm3.1Pisc/Ccne1tm3.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Ccne1tm3.1Pisc/Ccne1tm3.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0008441 thin cortical plate "reduced thickness of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: Ccne1tm3.1Pisc/Ccne1tm3.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0008457 abnormal cortical intermediate zone morphology "any structural anomaly of the region of the developing mammalian cortex that extends between the ventricular zone and the cortical plate (CP); normally, the IZ is a region of tangential migration of cells, and at midgestation, the lower part of the IZ develops into the subventricular zone" [PMID:10632599]
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Allelic Composition: Ccne1tm3.1Pisc/Ccne1tm3.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccne1tm3.1Pisc/Ccne1tm3.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Ccne1tm3.1Pisc/Ccne1tm3.1Pisc,Ccne2tm1Pisc/Ccne2tm1Pisc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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