ENSMUSG00000048878


Mus musculus

Features
Gene ID: ENSMUSG00000048878
  
Biological name :Hexim1
  
Synonyms : Hexim1 / Protein HEXIM1 / Q8R409
  
Possible biological names infered from orthology : hexamethylene bisacetamide inducible 1 / O94992
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E1
Gene start: 103116231
Gene end: 103119725
  
Corresponding Affymetrix probe sets: 10381697 (MoGene1.0st)   1419359_at (Mouse Genome 430 2.0 Array)   1425937_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057339
NCBI entrez gene - 192231     See in Manteia.
MGI - MGI:2385923
RefSeq - NM_138753
RefSeq Peptide - NP_620092
swissprot - Q8R409
Ensembl - ENSMUSG00000048878
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hexim1ENSDARG00000036482Danio rerio
 HEXIM1ENSGALG00000041926Gallus gallus
 HEXIM1ENSG00000186834Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hexim2 / Q3TVI4 / Protein HEXIM2 / Q96MH2* / hexamethylene bisacetamide inducible 2*ENSMUSG0000004337234


Protein motifs (from Interpro)
Interpro ID Name
 IPR024872  HEXIM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0002218 activation of innate immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:1901798 positive regulation of signal transduction by p53 class mediator IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017069 snRNA binding ISS
 molecular_functionGO:0097322 7SK snRNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000277 abnormal heart shape "malformation of the form or the patterning of the heart" [J:18048]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * FVB/NJ

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * FVB/NJ

 MP:0004055 atrial hypoplasia "reduction in cell number of one or both of the two upper chambers of the heart" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:36567]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * FVB/NJ

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004111 abnormal coronary artery morphology "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004567 decreased myocardial fiber number "decreased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * FVB/NJ

 MP:0008772 enlarged heart ventricle "increased average size of the heart ventricles compared to the average for a particular population" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pthlhtm1Fbe/Pthlhtm1Fbe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008788 abnormal fetal cardiomyocyte morphology "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * FVB/NJ

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * FVB/NJ

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * FVB/NJ

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Luc)Kael/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * FVB/NJ

Allelic Composition: Hexim1Gt(XB322)Byg/Hexim1Gt(XB322)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr