ENSMUSG00000049625


Mus musculus

Features
Gene ID: ENSMUSG00000049625
  
Biological name :Tifab
  
Synonyms : Q8JZM6 / Tifab / TRAF-interacting protein with FHA domain-containing protein B
  
Possible biological names infered from orthology : Q6ZNK6 / TIFA inhibitor
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B1
Gene start: 56173704
Gene end: 56178885
  
Corresponding Affymetrix probe sets: 10409567 (MoGene1.0st)   1436397_at (Mouse Genome 430 2.0 Array)   1444546_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131162
Ensembl peptide - ENSMUSP00000152976
NCBI entrez gene - 212937     See in Manteia.
MGI - MGI:2385852
RefSeq - XM_006517205
RefSeq - NM_001168615
RefSeq - NM_145976
RefSeq - XM_006517204
RefSeq Peptide - NP_001162086
RefSeq Peptide - NP_666088
swissprot - Q8JZM6
Ensembl - ENSMUSG00000049625
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TIFABENSG00000255833Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR008984  SMAD/FHA domain superfamily
 IPR033621  TRAF-interacting protein with FHA domain-containing protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0007356 thorax and anterior abdomen determination ISO
 biological_processGO:0021559 trigeminal nerve development ISO
 biological_processGO:0021650 vestibulocochlear nerve formation ISO
 biological_processGO:0030432 peristalsis ISO
 biological_processGO:0031223 auditory behavior ISO
 biological_processGO:0035112 genitalia morphogenesis ISO
 biological_processGO:0042472 inner ear morphogenesis ISO
 biological_processGO:0048634 regulation of muscle organ development ISO
 biological_processGO:0048806 genitalia development ISO
 biological_processGO:0048839 inner ear development ISO
 biological_processGO:0050885 neuromuscular process controlling balance ISO
 biological_processGO:0060021 roof of mouth development ISO
 biological_processGO:0071626 mastication ISO
 biological_processGO:0090102 cochlea development ISO
 biological_processGO:0090103 cochlea morphogenesis ISO
 biological_processGO:0097094 craniofacial suture morphogenesis ISO
 biological_processGO:0098583 learned vocalization behavior ISO
 biological_processGO:1901078 negative regulation of relaxation of muscle ISO
 biological_processGO:1905747 negative regulation of saliva secretion ISO
 biological_processGO:1905748 hard palate morphogenesis ISO
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Mir146tm1.1Bal/Mir146tm1.1Bal,Tifabtm1.1Dsta/Tifabtm1.1Dsta
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Tifabtm1.1Dsta/Tifab+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Tifabtm1.1Dsta/Tifab+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Tifabtm1.1Dsta/Tifab+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

Allelic Composition: Mir146tm1.1Bal/Mir146tm1.1Bal,Tifabtm1.1Dsta/Tifabtm1.1Dsta
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Mir146tm1.1Bal/Mir146tm1.1Bal,Tifabtm1.1Dsta/Tifabtm1.1Dsta
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0005065 abnormal neutrophil morphology "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011182 decreased hematopoietic cell number "fewer than expected number of cells of the hematopoietic lineage" [MGI:csmith]
Show

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Tifabtm1.1Dsta/Tifab+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0011903 decreased hematopoietic stem cell proliferation "reduction in the expansion rate of a hematopoietic stem cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Col1a1tm2(tetO-GFP/RNAi:Smc1a)Iaai/Col1a1tm3(tetO-GFP/RNAi:Stag2)Iaai,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Tifabtm1.1Dsta/Tifab+
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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