ENSMUSG00000049699


Mus musculus

Features
Gene ID: ENSMUSG00000049699
  
Biological name :Ucn2
  
Synonyms : Q99ML8 / Ucn2 / urocortin 2
  
Possible biological names infered from orthology : Q96RP3
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F2
Gene start: 108986010
Gene end: 108987164
  
Corresponding Affymetrix probe sets: 10589327 (MoGene1.0st)   1450607_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000060405
NCBI entrez gene - 171530     See in Manteia.
MGI - MGI:2176375
RefSeq - NM_145077
RefSeq Peptide - NP_659543
swissprot - Q99ML8
Ensembl - ENSMUSG00000049699
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 UCN2ENSG00000145040Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000187  Corticotropin-releasing factor
 IPR024270  Urocortin II/III
 IPR024273  Urocortin II


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006950 response to stress IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007586 digestion IEA
 biological_processGO:0009755 hormone-mediated signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0031669 cellular response to nutrient levels IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IDA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042562 hormone binding IEA
 molecular_functionGO:0051429 corticotropin-releasing hormone receptor binding ISS
 molecular_functionGO:0051431 corticotropin-releasing hormone receptor 2 binding IEA


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001422 abnormal drinking behavior "an altered pattern of fluid consumption or altered preference for particular fluids" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0001748 increased circulating adrenocorticotropin level "elevated concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003476 Crhr2 / Q60748 / Corticotropin-releasing factor receptor 2 / Q13324* / corticotropin releasing hormone receptor 2*  / complex / reaction






 

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