Manteia - Molecule gene

ENSMUSG00000049800

Mus musculus

Features

Gene ID:	ENSMUSG00000049800

Biological name :	Sertad2

Synonyms :	Q9JJG5 / Sertad2 / SERTA domain containing 2

Possible biological names infered from orthology :	Q14140

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	A3.1
Gene start:	20543253
Gene end:	20653021

Corresponding Affymetrix probe sets:	10374478 (MoGene1.0st) 1417209_at (Mouse Genome 430 2.0 Array) 1454815_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000090981 Ensembl peptide - ENSMUSP00000105214 Ensembl peptide - ENSMUSP00000105215 NCBI entrez gene - 58172 See in Manteia. MGI - MGI:1931026 RefSeq - XM_006514766 RefSeq - NM_001038625 RefSeq - NM_021372 RefSeq Peptide - NP_067347 RefSeq Peptide - NP_001033714 swissprot - Q3UGZ1 swissprot - Q9JJG5 Ensembl - ENSMUSG00000049800

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
sertad2b	ENSDARG00000055530	Danio rerio
SERTAD2	ENSGALG00000026298	Gallus gallus
Q14140	ENSG00000179833	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Cdca4 / Q9CWM2 / Mus musculus cell division cycle associated 4 (Cdca4), transcript variant 2, mRNA. / Q9BXL8* / cell division cycle associated 4*	ENSMUSG00000047832	23

Protein motifs (from Interpro)

Interpro ID	Name
IPR009263	SERTA domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0030308	negative regulation of cell growth	ISA
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IDA
cellular_component	GO:0005634	nucleus	ISA
cellular_component	GO:0005654	nucleoplasm	ISO
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	ISO
molecular_function	GO:0003713	transcription coactivator activity	IDA
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
MP:0002118	abnormal lipid homeostasis	"anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
MP:0002310	resistance to fatty liver development	"less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0002451	abnormal macrophage physiology	"abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0002891	increased insulin sensitivity	"greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]	Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0003402	decreased liver weight	"reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0003953	abnormal hormone level	"aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0003960	increased lean body mass	"more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0004892	increased adiponectin level	"greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0005289	increased oxygen consumption	"greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0005292	improved glucose tolerance	"better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0005418	abnormal circulating hormone level	"anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0005459	decreased percent body fat	"less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0005659	resistance to diet-induced obesity	"less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]	Show Allelic Composition: Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0005668	decreased circulating leptin level	"less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]	Show Allelic Composition: Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0008034	enhanced lipolysis	"increase in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0008844	decreased subcutaneous adipose tissue amount	"reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0009127	increased brown fat cell number	"increase in the number of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0009133	decreased white fat cell size	"reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0009136	decreased brown fat cell size	"reduction in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322]	Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0009289	decreased epididymal fat pad weight		Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0009356	decreased liver triglyceride level	"lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0011016	increased core body temperature	"increased degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}
MP:0011704	decreased fibroblast proliferation	"reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]	Show Allelic Composition: Ptpmt1^tm2.1Ckq/Ptpmt1^tm2.1Ckq,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
MP:0014169	decreased brown adipose tissue mass	"decreased physical bulk or volume of brown adipose tissue" [MGI:csmith]	Show Allelic Composition: Sertad2^{Gt(OST98734)Lex}/Sertad2^{Gt(OST98734)Lex} Genetic Background: B6.129S5-Sertad2^{Gt(OST98734)Lex}

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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