Manteia

ENSMUSG00000049811

Mus musculus

Features

Gene ID:	ENSMUSG00000049811

Biological name :	Fam161a

Synonyms :	Fam161a

Possible biological names infered from orthology :	family with sequence similarity 161 member A / Q3B820

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	A3.2
Gene start:	23007531
Gene end:	23030788

Corresponding Affymetrix probe sets:	10374578 (MoGene1.0st) 1443569_at (Mouse Genome 430 2.0 Array) 1451653_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000105184 Ensembl peptide - ENSMUSP00000121167 Ensembl peptide - ENSMUSP00000146368 Ensembl peptide - ENSMUSP00000134485 Ensembl peptide - ENSMUSP00000133293 Ensembl peptide - ENSMUSP00000063091 Ensembl peptide - ENSMUSP00000091923 NCBI entrez gene - 73873 See in Manteia. MGI - MGI:1921123 RefSeq - XM_017314799 RefSeq - XM_006514834 RefSeq - XM_006514836 RefSeq - XM_006514837 RefSeq - XM_006514838 RefSeq - XM_006514839 RefSeq - XM_011243762 RefSeq - NM_028672 RefSeq - XM_006514828 RefSeq - XM_006514829 RefSeq - XM_006514832 RefSeq - XM_006514833 RefSeq Peptide - NP_082948 swissprot - B1AVK0 swissprot - A0A1B0GXD7 swissprot - F6XT74 swissprot - A0A140LHD1 swissprot - B1AVK2 Ensembl - ENSMUSG00000049811

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
fam161a	ENSDARG00000089742	Danio rerio
FAM161A	ENSGALG00000008810	Gallus gallus
Q3B820	ENSG00000170264	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q8CB59 / Fam161b / Mus musculus family with sequence similarity 161, member B (Fam161b), transcript variant 2, mRNA. / Q96MY7* / family with sequence similarity 161 member B*	ENSMUSG00000021234	22

Protein motifs (from Interpro)

Interpro ID	Name
IPR011990	Tetratricopeptide-like helical domain superfamily
IPR019579	Uncharacterised protein family UPF0564

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
molecular_function	GO:0005515	protein binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000947	convulsive seizures	"seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fadd^{tm1e.1(KOMP)Wtsi}/Fadd^{tm1e.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Fadd^{tm1e.1(KOMP)Wtsi}/Ucd
MP:0001004	abnormal photoreceptor morphology	"structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Scn11a^tm1Gsk/Scn11a^tm1Gsk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001326	retinal degeneration	"pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]	Show Allelic Composition: Scn11a^tm1Gsk/Scn11a^tm1Gsk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001417	decreased exploration in new environment	"less amount of time spent investigating a new location" [J:79870]	Show Allelic Composition: Fadd^{tm1e.1(KOMP)Wtsi}/Fadd^{tm1e.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Fadd^{tm1e.1(KOMP)Wtsi}/Ucd
MP:0001488	increased startle reflex	"reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Fadd^{tm1e.1(KOMP)Wtsi}/Fadd^{tm1e.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Fadd^{tm1e.1(KOMP)Wtsi}/Ucd
MP:0002090	abnormal vision	"inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Scn11a^tm1Gsk/Scn11a^tm1Gsk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002626	increased heart rate	"greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Fadd^{tm1e.1(KOMP)Wtsi}/Fadd^{tm1e.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Fadd^{tm1e.1(KOMP)Wtsi}/Ucd
MP:0003064	decreased coping response	"reduced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]	Show Allelic Composition: Fadd^{tm1e.1(KOMP)Wtsi}/Fadd^{tm1e.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Fadd^{tm1e.1(KOMP)Wtsi}/Ucd
MP:0003729	abnormal photoreceptor outer segments	"malformation/anomalous structure of the photoreceptor layer which contains stacks of membranous discs that are rich in the visual pigment rhodopsin " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Scn11a^tm1Gsk/Scn11a^tm1Gsk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008450	retinal photoreceptor degeneration	"a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Scn11a^tm1Gsk/Scn11a^tm1Gsk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008515	thin retinal outer nuclear layer	"reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Scn11a^tm1Gsk/Scn11a^tm1Gsk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008518	retinal outer nuclear layer degeneration	"a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Scn11a^tm1Gsk/Scn11a^tm1Gsk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008586	disorganized photoreceptor outer segment	"derangement of the pattern of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Scn11a^tm1Gsk/Scn11a^tm1Gsk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008918	microgliosis	"a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Scn11a^tm1Gsk/Scn11a^tm1Gsk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010052	increased grip strength	"greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Fadd^{tm1e.1(KOMP)Wtsi}/Fadd^{tm1e.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Fadd^{tm1e.1(KOMP)Wtsi}/Ucd
MP:0010507	shortened RR interval	"reduction in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fadd^{tm1e.1(KOMP)Wtsi}/Fadd^{tm1e.1(KOMP)Wtsi} Genetic Background: C57BL/6N-Fadd^{tm1e.1(KOMP)Wtsi}/Ucd
MP:0012029	abnormal electroretinogram waveform feature	"any anomaly in the pattern of the graphic record of the integrated ensemble response from many vision related neuronal and glial populations as a consequence of the serial processing within the retina, represented as changes in voltage over time after visual photonic stimulation" [MGI:csmith]	Show Allelic Composition: Scn11a^tm1Gsk/Scn11a^tm1Gsk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0012143	decreased a wave amplitude	"reduction in the size (height or maximum displacement) of the a wave as measured in the electroretinogram" [MGI:csmith]	Show Allelic Composition: Scn11a^tm1Gsk/Scn11a^tm1Gsk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0012144	decreased b wave amplitude	"reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith]	Show Allelic Composition: Scn11a^tm1Gsk/Scn11a^tm1Gsk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0012147	increased a wave implicit time	"increase in the time from the onset of light stimulus to the peak of the a wave" [MGI:smb]	Show Allelic Composition: Scn11a^tm1Gsk/Scn11a^tm1Gsk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0012150	increased b wave implicit time	"increase in the time from the onset of light stimulus to the peak of the b wave" [MGI:smb]	Show Allelic Composition: Scn11a^tm1Gsk/Scn11a^tm1Gsk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0014059	abnormal photoreceptor connecting cilium morphology	"any structural anomaly of the nonmotile primary cilium that has a 9+0 microtubule array and forms the portion of the axoneme traversing the boundary between the retinal photoreceptor inner and outer segments" [GO:0032391, PMID:20212494]	Show Allelic Composition: Scn11a^tm1Gsk/Scn11a^tm1Gsk Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0030005	increased retinal apoptosis	"increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Scn11a^tm1Gsk/Scn11a^tm1Gsk Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr