ENSMUSG00000050089


Mus musculus

Features
Gene ID: ENSMUSG00000050089
  
Biological name :Akap4
  
Synonyms : Akap4 / A-kinase anchor protein 4 / Q60662
  
Possible biological names infered from orthology : A-kinase anchoring protein 4 / Q5JQC9
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A1.1
Gene start: 7067519
Gene end: 7078609
  
Corresponding Affymetrix probe sets: 10598279 (MoGene1.0st)   1419019_a_at (Mouse Genome 430 2.0 Array)   1451661_at (Mouse Genome 430 2.0 Array)   1451662_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000111417
Ensembl peptide - ENSMUSP00000050962
Ensembl peptide - ENSMUSP00000111416
NCBI entrez gene - 11643     See in Manteia.
MGI - MGI:102794
RefSeq - NM_001042542
RefSeq - NM_009651
RefSeq Peptide - NP_001036007
RefSeq Peptide - NP_033781
swissprot - A1L3T6
swissprot - Q60662
Ensembl - ENSMUSG00000050089
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AKAP4ENSG00000147081Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Akap3 / O88987 / A-kinase anchor protein 3 / O75969* / A-kinase anchoring protein 3*ENSMUSG0000003034436


Protein motifs (from Interpro)
Interpro ID Name
 IPR008382  SPHK1-interactor/A-kinase anchor 110kDa
 IPR018292  A-kinase anchor 110kDa, C-terminal
 IPR018459  RII binding domain
 IPR020799  A-kinase anchor 110kDa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IPI
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0010738 regulation of protein kinase A signaling IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030317 flagellated sperm motility IMP
 biological_processGO:0044458 motile cilium assembly IMP
 biological_processGO:0045184 establishment of protein localization IMP
 cellular_componentGO:0005929 cilium IDA
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0035686 sperm fibrous sheath IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0097228 sperm principal piece IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0051018 protein kinase A binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Krastm1Epa/Krastm1Epa
Genetic Background: 129P2/OlaHsd-Krastm1Epa

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm1Epa/Krastm1Epa
Genetic Background: 129P2/OlaHsd-Krastm1Epa

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Krastm1Epa/Krastm1Epa
Genetic Background: 129P2/OlaHsd-Krastm1Epa

 MP:0009238 coiled sperm flagellum "abnormal twisting of the sperm flagellum into coils or spirals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm1Epa/Krastm1Epa
Genetic Background: 129P2/OlaHsd-Krastm1Epa

 MP:0009239 short sperm flagellum "decreased length of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm1Epa/Krastm1Epa
Genetic Background: 129P2/OlaHsd-Krastm1Epa

 MP:0009280 reduced activated sperm motility "loss or reduction of the activated type of sperm mobility, resulting in immotile sperm that are generally unable to reach the uterotubal junction; decreases in activated sperm motility may result in reduced male fertility" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm1Epa/Krastm1Epa
Genetic Background: 129P2/OlaHsd-Krastm1Epa

 MP:0009282 reduced hyperactivated sperm motility "loss or reduction of the hyperactivated type of sperm mobility, impairing the ability of sperm to reach the site of fertilization and to penetrate the oocyte vestments; a block in hyperactivated motility may also impair the ability of a sperm to fertilize an oocyte in vitro" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm1Epa/Krastm1Epa
Genetic Background: 129P2/OlaHsd-Krastm1Epa

 MP:0009832 abnormal sperm mitochondrial sheath morphology "any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499]
Show

Allelic Composition: Krastm1Epa/Krastm1Epa
Genetic Background: 129P2/OlaHsd-Krastm1Epa

 MP:0009836 abnormal sperm principal piece morphology "any structural abnormality in the segment of the sperm flagellum where the mitochondrial sheath ends and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs; the principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece" [PMID:14581499]
Show

Allelic Composition: Krastm1Epa/Krastm1Epa
Genetic Background: 129P2/OlaHsd-Krastm1Epa

 MP:0009837 abnormal sperm end piece morphology "any structural abnormality in the short remaining region of the sperm flagellum, which contains only the axoneme surrounded by the plasma membrane" [PMID:14581499]
Show

Allelic Composition: Krastm1Epa/Krastm1Epa
Genetic Background: 129P2/OlaHsd-Krastm1Epa

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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