ENSMUSG00000050860


Mus musculus

Features
Gene ID: ENSMUSG00000050860
  
Biological name :Phospho1
  
Synonyms : Phospho1 / Phosphoethanolamine/phosphocholine phosphatase / Q8R2H9
  
Possible biological names infered from orthology : Q8TCT1
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 95824499
Gene end: 95832140
  
Corresponding Affymetrix probe sets: 10380566 (MoGene1.0st)   1452485_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135721
Ensembl peptide - ENSMUSP00000057858
Ensembl peptide - ENSMUSP00000117244
NCBI entrez gene - 237928     See in Manteia.
MGI - MGI:2447348
RefSeq - NM_153104
RefSeq Peptide - NP_694744
swissprot - Q8R2H9
swissprot - F6Y6Q2
swissprot - H3BLB1
Ensembl - ENSMUSG00000050860
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phospho1ENSDARG00000008403Danio rerio
 PHOSPHO1ENSGALG00000033683Gallus gallus
 Q8TCT1ENSG00000173868Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9D9M5 / Phospho2 / Pyridoxal phosphate phosphatase PHOSPHO2 / Q8TCD6* / phosphatase, orphan 2*ENSMUSG0000002708836


Protein motifs (from Interpro)
Interpro ID Name
 IPR006384  Pyridoxal phosphate phosphatase-related
 IPR016965  Phosphatase PHOSPHO-type
 IPR023214  HAD superfamily
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001958 endochondral ossification IMP
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030500 regulation of bone mineralization IEA
 biological_processGO:0035630 bone mineralization involved in bone maturation IMP
 cellular_componentGO:0065010 extracellular membrane-bounded organelle ISO
 molecular_functionGO:0016462 pyrophosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0052731 phosphocholine phosphatase activity ISO
 molecular_functionGO:0052732 phosphoethanolamine phosphatase activity ISO


Pathways (from Reactome)
Pathway description
Synthesis of PC
Synthesis of PE


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000061 fragile skeleton "easily damaged or broken bones" [J:14208]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Alpltm1Jlm/Alpl+,Phospho1m1Jlm/Phospho1m1Jlm
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6

 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Alpltm1Jlm/Alpl+,Phospho1m1Jlm/Phospho1m1Jlm
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Alpltm1Jlm/Alpl+,Phospho1m1Jlm/Phospho1m1Jlm
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003795 abnormal bone structure 
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004358 bowed tibia "increased curvature of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Alpltm1Jlm/Alpl+,Phospho1m1Jlm/Phospho1m1Jlm
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6

 MP:0004361 bowed ulna "increased curvature of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004371 bowed femur "increased curvature of the long bone of the thigh" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004372 bowed fibula "increased curvature of the lateral and smaller bone of the lower limb" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004373 bowed humerus "increased curvature of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004374 bowed radius "increased curvature of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005298 abnormal clavicle morphology "malformation of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008274 failure of bone ossification "failure to initiate or a block in the process of the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009445 osteomalacia "gradual softening and bending of the bones due to failure of osteoid tissue to calcify as a result of vitamin D deficiency or renal tubular dysfunction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009780 abnormal chondrocyte physiology "any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Alpltm1Jlm/Alpl+,Phospho1m1Jlm/Phospho1m1Jlm
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Alpltm1Jlm/Alpl+,Phospho1m1Jlm/Phospho1m1Jlm
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011942 decreased fluid intake "reduction in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Porcntm1.1Lcm/Y,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Alpltm1Jlm/Alpl+,Phospho1m1Jlm/Phospho1m1Jlm
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
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Allelic Composition: Alpltm1Jlm/Alpl+,Phospho1m1Jlm/Phospho1m1Jlm
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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