ENSMUSG00000050957


Mus musculus

Features
Gene ID: ENSMUSG00000050957
  
Biological name :Insl6
  
Synonyms : Insl6 / Insulin-like peptide INSL6 Insulin-like peptide INSL6 B chain Insulin-like peptide INSL6 A chain / Q9QY05
  
Possible biological names infered from orthology : insulin like 6 / Q9Y581
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C1
Gene start: 29321344
Gene end: 29325356
  
Corresponding Affymetrix probe sets: 10466932 (MoGene1.0st)   1418346_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054488
NCBI entrez gene - 27356     See in Manteia.
MGI - MGI:1351595
RefSeq - NM_013754
RefSeq Peptide - NP_038782
swissprot - Q545M1
swissprot - Q9QY05
Ensembl - ENSMUSG00000050957
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 INSL6ENSG00000120210Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR016179  Insulin-like
 IPR017100  Insulin-like peptide 6
 IPR022353  Insulin, conserved site
 IPR036438  Insulin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030317 flagellated sperm motility IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005179 hormone activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Ppp1r3btm1.1Arte/Ppp1r3b+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Ppp1r3btm1.1Arte/Ppp1r3b+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Insl6tm1Imad/Insl6tm1Imad
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Insl6tm1Imad/Insl6tm1Imad
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp1r3btm1.1Arte/Ppp1r3b+
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Insl6tm1Imad/Insl6tm1Imad
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Insl6tm1Imad/Insl6tm1Imad
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Insl6tm1Imad/Insl6tm1Imad
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Insl6tm1Imad/Insl6tm1Imad
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insl6tm1Imad/Insl6tm1Imad
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insl6tm1Imad/Insl6tm1Imad
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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