ENSMUSG00000050989


Mus musculus

Features
Gene ID: ENSMUSG00000050989
  
Biological name :Selenon
  
Synonyms : D3Z2R5 / Selenon / Selenoprotein N
  
Possible biological names infered from orthology : AL020996.2 / Q9NZV5
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D3
Gene start: 134537892
Gene end: 134552166
  
Corresponding Affymetrix probe sets: 10517274 (MoGene1.0st)   1426680_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000060026
NCBI entrez gene - 74777     See in Manteia.
MGI - MGI:2151208
RefSeq - NM_029100
RefSeq Peptide - NP_083376
swissprot - D3Z2R5
Ensembl - ENSMUSG00000050989
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 selenonENSDARG00000033616Danio rerio
 SELENONENSGALG00000001003Gallus gallus
 AL020996.2ENSG00000255054Homo sapiens
 Q9NZV5ENSG00000162430Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003016 respiratory system process IMP
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0014816 skeletal muscle satellite cell differentiation IMP
 biological_processGO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IMP
 biological_processGO:0014858 positive regulation of skeletal muscle cell proliferation IDA
 biological_processGO:0014873 response to muscle activity involved in regulation of muscle adaptation IMP
 biological_processGO:0033555 multicellular organismal response to stress IMP
 biological_processGO:0034599 cellular response to oxidative stress IMP
 biological_processGO:0043403 skeletal muscle tissue regeneration IMP
 biological_processGO:0048286 lung alveolus development IMP
 biological_processGO:0048741 skeletal muscle fiber development IMP
 biological_processGO:0055074 calcium ion homeostasis ISS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060314 regulation of ryanodine-sensitive calcium-release channel activity ISO
 biological_processGO:0071313 cellular response to caffeine IMP
 biological_processGO:1902884 positive regulation of response to oxidative stress ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Selenontm1.2Mred/Selenontm1.2Mred
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
Show

Allelic Composition: Wnt11tm1.1Khay/Wnt11tm1.2Khay,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Selenontm1.2Mred/Selenontm1.2Mred
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Selenontm1Begg/Selenontm1Begg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Kittm5.1Bsm/Kit+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Kittm5.1Bsm/Kit+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0001942 abnormal lung volume "anomaly in the amount of air that the lungs contain at various points of the respiratory cycle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Selenontm1Begg/Selenontm1Begg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wnt11tm1.1Khay/Wnt11tm1.2Khay,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Selenontm1.2Mred/Selenontm1.2Mred
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kittm5.1Bsm/Kit+
Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: F8tm2Kaz/Y
Genetic Background: involves: 129S4/SvJae

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Selenontm1Begg/Selenontm1Begg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0003833 decreased number of satellite cells "less than the normal number of unfused cells in muscle that play a role in muscle regeneration" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Wnt11tm1.1Khay/Wnt11tm1.2Khay,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0004609 vertebral fusion "the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rnf10tm1a(KOMP)Wtsi/Rnf10tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Rnf10tm1a(KOMP)Wtsi/Wtsi

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selenontm1.2Mred/Selenontm1.2Mred
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Selenontm1Begg/Selenontm1Begg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0009400 decreased skeletal muscle fiber size "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selenontm1.2Mred/Selenontm1.2Mred
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selenontm1.2Mred/Selenontm1.2Mred
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selenontm1.2Mred/Selenontm1.2Mred
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selenontm1.2Mred/Selenontm1.2Mred
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0009417 skeletal muscle atrophy "a wasting of skeletal muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Wnt11tm1.1Khay/Wnt11tm1.2Khay,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Selenontm1.2Mred/Selenontm1.2Mred
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0009422 decreased gastrocnemius weight "reduction in the weight of the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Selenontm1.2Mred/Selenontm1.2Mred
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0009424 decreased extensor digitorum longus weight "reduction in the weight of the penniform muscle of the lateral front part of the leg responsible for extension of the toes and dorsiflexion of the ankle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selenontm1.2Mred/Selenontm1.2Mred
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0009426 decreased soleus weight "reduction in the weight of the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selenontm1.2Mred/Selenontm1.2Mred
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0009428 decreased tibialis anterior weight "redcution in the weight of the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selenontm1.2Mred/Selenontm1.2Mred
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0009461 skeletal muscle hypertrophy "increase in the bulk size of the skeletal muscle due to cell enlargement" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selenontm1Begg/Selenontm1Begg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0010182 decreased susceptibility to weight gain "smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selenontm1.2Mred/Selenontm1.2Mred
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0010227 decreased quadriceps weight "reduction in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Selenontm1.2Mred/Selenontm1.2Mred
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

 MP:0010895 increased lung compliance "increased ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"]
Show

Allelic Composition: Selenontm1Begg/Selenontm1Begg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0010902 abnormal pulmonary alveolar sac morphology "any structural anomaly of the small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Selenontm1Begg/Selenontm1Begg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0011045 decreased lung elastance "reduced ability of the lung to recoil toward its resting dimensions upon removal of pressure without disruption, usually expressed as the unit volume of change in the lung per unit of decreased pressure change; the reciprocal of compliance" [MGI:anna]
Show

Allelic Composition: Selenontm1Begg/Selenontm1Begg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0012107 enhanced exercise endurance "improved performance during controlled physical activity" [MGI:smb]
Show

Allelic Composition: Selenontm1Begg/Selenontm1Begg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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