ENSMUSG00000051455


Mus musculus

Features
Gene ID: ENSMUSG00000051455
  
Biological name :Meioc
  
Synonyms : A2AG06 / Meioc / Meiosis-specific coiled-coil domain-containing protein MEIOC
  
Possible biological names infered from orthology : A2RUB1 / meiosis specific with coiled-coil domain
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E1
Gene start: 102663716
Gene end: 102682237
  
Corresponding Affymetrix probe sets: 10381608 (MoGene1.0st)   1437678_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097947
Ensembl peptide - ENSMUSP00000116246
NCBI entrez gene - 268491     See in Manteia.
MGI - MGI:2686410
RefSeq - NM_001127576
RefSeq - XM_006533415
RefSeq - XM_006533416
RefSeq Peptide - NP_001121048
swissprot - A2AG06
swissprot - A0A0R3P9D4
Ensembl - ENSMUSG00000051455
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 motoENSDARG00000090664Danio rerio
 MEIOCENSGALG00000045889Gallus gallus
 MEIOCENSG00000180336Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR027963  Meiosis-specific coiled-coil domain-containing protein MEIOC


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006302 double-strand break repair IMP
 biological_processGO:0007130 synaptonemal complex assembly IMP
 biological_processGO:0007141 male meiosis I IMP
 biological_processGO:0007144 female meiosis I IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0048255 mRNA stabilization IMP
 biological_processGO:0048599 oocyte development IMP
 biological_processGO:0051310 metaphase plate congression IMP
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0051729 germline cell cycle switching, mitotic to meiotic cell cycle IMP
 biological_processGO:0070192 chromosome organization involved in meiotic cell cycle IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Tprnem1Pghu/Tprnem1Pghu
Genetic Background: B6.Cg-Tprnem1Pghu

Allelic Composition: Meioctm1c(KOMP)Wtsi/Meioctm1c(KOMP)Wtsi,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Tprnem1Pghu/Tprnem1Pghu
Genetic Background: B6.Cg-Tprnem1Pghu

Allelic Composition: Meioctm1c(KOMP)Wtsi/Meioctm1c(KOMP)Wtsi,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Tprnem1Pghu/Tprnem1Pghu
Genetic Background: B6.Cg-Tprnem1Pghu

Allelic Composition: Meioctm1c(KOMP)Wtsi/Meioctm1c(KOMP)Wtsi,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Tprnem1Pghu/Tprnem1Pghu
Genetic Background: B6.Cg-Tprnem1Pghu

Allelic Composition: Meioctm1c(KOMP)Wtsi/Meioctm1c(KOMP)Wtsi,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tprnem1Pghu/Tprnem1Pghu
Genetic Background: B6.Cg-Tprnem1Pghu

Allelic Composition: Meioctm1c(KOMP)Wtsi/Meioctm1c(KOMP)Wtsi,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB

 MP:0004805 absent oocytes "absence of mature germ cells in the female" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tprnem1Pghu/Tprnem1Pghu
Genetic Background: B6.Cg-Tprnem1Pghu

Allelic Composition: Meioctm1a(KOMP)Wtsi/Meioctm1a(KOMP)Wtsi,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tprnem1Pghu/Tprnem1Pghu
Genetic Background: B6.Cg-Tprnem1Pghu

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tprnem1Pghu/Tprnem1Pghu
Genetic Background: B6.Cg-Tprnem1Pghu

Allelic Composition: Meioctm1a(KOMP)Wtsi/Meioctm1a(KOMP)Wtsi,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6N

Allelic Composition: Meioctm1c(KOMP)Wtsi/Meioctm1c(KOMP)Wtsi,Tg(Ddx4-cre)1Dcas/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tprnem1Pghu/Tprnem1Pghu
Genetic Background: B6.Cg-Tprnem1Pghu

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tprnem1Pghu/Tprnem1Pghu
Genetic Background: B6.Cg-Tprnem1Pghu

Allelic Composition: Meioctm1a(KOMP)Wtsi/Meioctm1a(KOMP)Wtsi,Spo11tm1Mjn/Spo11tm1Mjn
Genetic Background: involves: 129X1/SvJ * C57BL/6N

 MP:0009452 abnormal synaptonemal complex "an anomaly in the formation of the proteinaceous structure involved in the pairing of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tprnem1Pghu/Tprnem1Pghu
Genetic Background: B6.Cg-Tprnem1Pghu

 MP:0010767 abnormal female meiosis I arrest "any anomaly in the process in which oocytes stop at the diplotene stage of meiosis I and lie dormant, often for long periods of time" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tprnem1Pghu/Tprnem1Pghu
Genetic Background: B6.Cg-Tprnem1Pghu

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
Show

Allelic Composition: Tprnem1Pghu/Tprnem1Pghu
Genetic Background: B6.Cg-Tprnem1Pghu

 MP:0014052 increased male germ cell apoptosis "greater number of male germs cells that undergo programmed cell death" [MGI:csmith]
Show

Allelic Composition: Tprnem1Pghu/Tprnem1Pghu
Genetic Background: B6.Cg-Tprnem1Pghu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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