ENSMUSG00000051495


Mus musculus

Features
Gene ID: ENSMUSG00000051495
  
Biological name :Irf2bp2
  
Synonyms : E9Q1P8 / Interferon regulatory factor 2-binding protein 2 / Irf2bp2
  
Possible biological names infered from orthology : Q7Z5L9
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E2
Gene start: 126588296
Gene end: 126593986
  
Corresponding Affymetrix probe sets: 10582811 (MoGene1.0st)   1433632_at (Mouse Genome 430 2.0 Array)   1433633_at (Mouse Genome 430 2.0 Array)   1433634_at (Mouse Genome 430 2.0 Array)   1454665_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062753
NCBI entrez gene - 270110     See in Manteia.
MGI - MGI:2443921
RefSeq - NM_001164598
RefSeq Peptide - NP_001158070
swissprot - E9Q1P8
Ensembl - ENSMUSG00000051495
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irf2bp2aENSDARG00000004702Danio rerio
 irf2bp2bENSDARG00000098635Danio rerio
 IRF2BP2ENSGALG00000010996Gallus gallus
 Q7Z5L9ENSG00000168264Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8K3X4 / Irf2bpl / Interferon regulatory factor 2-binding protein-like / Q9H1B7*ENSMUSG0000003416852
Q8R3Y8 / Irf2bp1 / Interferon regulatory factor 2-binding protein 1 / Q8IU81*ENSMUSG0000004403039


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR022750  Interferon regulatory factor 2-binding protein 1 & 2, zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003714 transcription corepressor activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Trim71Gt(H004C06)Wrst/Trim71Gt(H004C06)Wrst
Genetic Background: B6J.129S2-Trim71Gt(H004C06)Wrst

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trim71Gt(H004C06)Wrst/Trim71Gt(H004C06)Wrst
Genetic Background: B6J.129S2-Trim71Gt(H004C06)Wrst

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trim71Gt(H004C06)Wrst/Trim71Gt(H004C06)Wrst
Genetic Background: B6J.129S2-Trim71Gt(H004C06)Wrst

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trim71Gt(H004C06)Wrst/Trim71Gt(H004C06)Wrst
Genetic Background: B6J.129S2-Trim71Gt(H004C06)Wrst

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trim71Gt(H004C06)Wrst/Trim71Gt(H004C06)Wrst
Genetic Background: B6J.129S2-Trim71Gt(H004C06)Wrst

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trim71Gt(H004C06)Wrst/Trim71Gt(H004C06)Wrst
Genetic Background: B6J.129S2-Trim71Gt(H004C06)Wrst

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Trim71Gt(H004C06)Wrst/Trim71Gt(H004C06)Wrst
Genetic Background: B6J.129S2-Trim71Gt(H004C06)Wrst

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Trim71Gt(H004C06)Wrst/Trim71Gt(H004C06)Wrst
Genetic Background: B6J.129S2-Trim71Gt(H004C06)Wrst

 MP:0011178 increased erythroblast number "greater number of the nucleated precursor of erythrocytes" [MGI:csmith]
Show

Allelic Composition: Trim71Gt(H004C06)Wrst/Trim71Gt(H004C06)Wrst
Genetic Background: B6J.129S2-Trim71Gt(H004C06)Wrst

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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