ENSMUSG00000052819


Mus musculus

Features
Gene ID: ENSMUSG00000052819
  
Biological name :Best2
  
Synonyms : Best2 / bestrophin 2
  
Possible biological names infered from orthology : Q8NFU1
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C3
Gene start: 85007202
Gene end: 85014531
  
Corresponding Affymetrix probe sets: 10580286 (MoGene1.0st)   1425729_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147837
Ensembl peptide - ENSMUSP00000053408
Ensembl peptide - ENSMUSP00000147580
NCBI entrez gene - 212989     See in Manteia.
MGI - MGI:2387588
RefSeq - NM_001130194
RefSeq - XM_006530820
RefSeq - XM_011248341
RefSeq Peptide - NP_001123666
swissprot - A0A0R4J0P0
Ensembl - ENSMUSG00000052819
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 best2ENSDARG00000079163Danio rerio
 BEST2ENSG00000039987Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Best3 / Q6H1V1 / Bestrophin-3 / Q8N1M1*ENSMUSG0000002016954
Best1 / O88870 / Bestrophin-1 / O76090*ENSMUSG0000003741847


Protein motifs (from Interpro)
Interpro ID Name
 IPR000615  Bestrophin
 IPR021134  Bestrophin/UPF0187


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 molecular_functionGO:0005254 chloride channel activity IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005257 abnormal intraocular pressure "anomaly in the amount of force per unit area exerted by the intraocular fluid within the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col7a1tm1Lbt/Col7a1tm1Lbt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6Crl

Allelic Composition: Best2tm1Dgen/Best2+
Genetic Background: involves: C57BL/6

 MP:0005260 ocular hypotension "abnormally low intraocular pressure" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col7a1tm1Lbt/Col7a1tm1Lbt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6Crl

Allelic Composition: Best2tm1Dgen/Best2+
Genetic Background: involves: C57BL/6

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col7a1tm1Lbt/Col7a1tm1Lbt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6Crl

Allelic Composition: Best2tm1Dgen/Best2+
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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