ENSMUSG00000053863


Mus musculus

Features
Gene ID: ENSMUSG00000053863
  
Biological name :Mepe
  
Synonyms : Mepe
  
Possible biological names infered from orthology : matrix extracellular phosphoglycoprotein / Q9NQ76
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E5
Gene start: 104325329
Gene end: 104338611
  
Corresponding Affymetrix probe sets: 10523709 (MoGene1.0st)   1421650_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065200
NCBI entrez gene - 94111     See in Manteia.
MGI - MGI:2137384
RefSeq - NM_053172
RefSeq Peptide - NP_444402
swissprot - Q8K4L6
Ensembl - ENSMUSG00000053863
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MEPEENSG00000152595Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009837  Osteoregulin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development TAS
 biological_processGO:0030502 negative regulation of bone mineralization IMP
 molecular_functionGO:0005201 extracellular matrix structural constituent IBA
 molecular_functionGO:1990430 extracellular matrix protein binding IBA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irf8myls/Irf8myls
Genetic Background: involves: BALB/cJ * BXH2/TyJ-Irf8myls

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irf8myls/Irf8myls
Genetic Background: involves: BALB/cJ * BXH2/TyJ-Irf8myls

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irf8myls/Irf8myls
Genetic Background: involves: BALB/cJ * BXH2/TyJ-Irf8myls

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irf8myls/Irf8myls
Genetic Background: involves: BALB/cJ * BXH2/TyJ-Irf8myls

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irf8myls/Irf8myls
Genetic Background: involves: BALB/cJ * BXH2/TyJ-Irf8myls

 MP:0020080 increased bone mineralization "increase in the rate at which minerals are deposited into bone" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Irf8myls/Irf8myls
Genetic Background: involves: BALB/cJ * BXH2/TyJ-Irf8myls

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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