ENSMUSG00000054200


Mus musculus

Features
Gene ID: ENSMUSG00000054200
  
Biological name :Ffar4
  
Synonyms : Ffar4 / Free fatty acid receptor 4 / Q7TMA4
  
Possible biological names infered from orthology : Q5NUL3
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C2
Gene start: 38097079
Gene end: 38114263
  
Corresponding Affymetrix probe sets: 10462881 (MoGene1.0st)   1439489_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063660
NCBI entrez gene - 107221     See in Manteia.
MGI - MGI:2147577
RefSeq - NM_181748
RefSeq Peptide - NP_861413
swissprot - Q3V2S5
swissprot - Q7TMA4
Ensembl - ENSMUSG00000054200
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FFAR4ENSGALG00000026733Gallus gallus
 FFAR4ENSG00000186188Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0010827 regulation of glucose transmembrane transport IDA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0046879 hormone secretion IDA
 biological_processGO:0050710 negative regulation of cytokine secretion IDA
 biological_processGO:0050728 negative regulation of inflammatory response IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030139 endocytic vesicle IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IDA
 molecular_functionGO:0005504 fatty acid binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0008527 taste receptor activity IMP


Pathways (from Reactome)
Pathway description
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

 MP:0001985 abnormal gustatory system physiology "anomalous perception of taste" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001986 taste sensitivity/ preferences 
Show

Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

 MP:0002970 abnormal white fat morphology "structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Apctm1Tno/Apctm1Tno,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

 MP:0003564 abnormal insulin secretion "aberrant release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Letm1Gt(CC0204)Wtsi/Letm1+
Genetic Background: 129S.129P2-Letm1Gt(CC0204)Wtsi

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apctm1Tno/Apctm1Tno,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apctm1Tno/Apctm1Tno,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apctm1Tno/Apctm1Tno,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008953 abnormal pancreatic somatostatin secretion "anomaly in the production or release from pancreatic delta cells of a 14 amino acid peptide that inhibits growth hormone release and is found in the central and peripheral nervous systems, the gut, and other organs" [MESH:D06.472.699.327.700.875]
Show

Allelic Composition: Letm1Gt(CC0204)Wtsi/Letm1+
Genetic Background: 129S.129P2-Letm1Gt(CC0204)Wtsi

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

 MP:0009171 enlarged pancreatic islets "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

 MP:0010055 abnormal sensory neuron physiology "any functional anomaly of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of sensory impulses" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3c3tm1c(EUCOMM)Wtsi/Pik3c3tm1c(EUCOMM)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: C57BL/6 * C57BL/6N * C57BL/6NCrj * DBA

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Apctm1Tno/Apctm1Tno,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011169 abnormal white fat cell differentation "abnormal or arrest of differentiation of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500, MGI:csmith]
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Allelic Composition: Apctm1Tno/Apctm1Tno,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011170 abnormal brown fat cell differentiation "abnormal or arrest of differentiation of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals" [CL:0000449, MGI:csmith]
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Allelic Composition: Apctm1Tno/Apctm1Tno,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011698 abnormal brown adipose tissue physiology "any functional anomaly in the thermogenic form of adipose tissue that is composed of brown adipocytes" [MGI:smb]
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Allelic Composition: Apctm1Tno/Apctm1Tno,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0020426 abnormal beige fat cell physiology "any functional anomaly of fat cells that are beige in color, thermogenic, and which differentiates in white fat tissue from a Myf5-negative progenitor" [CL_0001070, PMID:22796012, PMID:23603813, PMID:24575370]
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Allelic Composition: Apctm1Tno/Apctm1Tno,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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