ENSMUSG00000054342


Mus musculus

Features
Gene ID: ENSMUSG00000054342
  
Biological name :Kcnn4
  
Synonyms : Kcnn4 / O89109 / potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
  
Possible biological names infered from orthology : O15554 / potassium calcium-activated channel subfamily N member 4
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A3
Gene start: 24370263
Gene end: 24386690
  
Corresponding Affymetrix probe sets: 10550877 (MoGene1.0st)   1421038_a_at (Mouse Genome 430 2.0 Array)   1435945_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133065
Ensembl peptide - ENSMUSP00000145873
Ensembl peptide - ENSMUSP00000146012
NCBI entrez gene - 16534     See in Manteia.
MGI - MGI:1277957
RefSeq - XM_006539563
RefSeq - NM_001163510
RefSeq - NM_008433
RefSeq Peptide - NP_001156982
RefSeq Peptide - NP_032459
swissprot - O89109
swissprot - A0A0U1RP82
Ensembl - ENSMUSG00000054342
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnn4ENSDARG00000086091Danio rerio
 KCNN4ENSG00000104783Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnn3 / P58391 / Small conductance calcium-activated potassium channel protein 3 / Q9UGI6* / potassium calcium-activated channel subfamily N member 3*ENSMUSG0000000079445
Kcnn2 / P58390 / potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 / Q9H2S1* / potassium calcium-activated channel subfamily N member 2*ENSMUSG0000005447744
Kcnn1 / potassium calcium-activated channel subfamily N member 1 / Q92952*ENSMUSG0000000290842


Protein motifs (from Interpro)
Interpro ID Name
 IPR004178  Calmodulin-binding domain
 IPR013099  Potassium channel domain
 IPR015449  Potassium channel, calcium-activated, SK
 IPR036122  SK, calmodulin-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006884 cell volume homeostasis IMP
 biological_processGO:0030322 stabilization of membrane potential IEA
 biological_processGO:0045332 phospholipid translocation IMP
 biological_processGO:0046541 saliva secretion IGI
 biological_processGO:0050714 positive regulation of protein secretion IDA
 biological_processGO:0050862 positive regulation of T cell receptor signaling pathway IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005887 integral component of plasma membrane IC
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0043025 neuronal cell body IBA
 molecular_functionGO:0005267 potassium channel activity IGI
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0015269 calcium-activated potassium channel activity ISO
 molecular_functionGO:0016286 small conductance calcium-activated potassium channel activity IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA


Pathways (from Reactome)
Pathway description
Ca2+ activated K+ channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cer1tm1Belo/Cer1tm1Belo
Genetic Background: involves: 129X1/SvJ

 MP:0000248 macrocytosis "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cer1tm1Belo/Cer1tm1Belo
Genetic Background: involves: 129X1/SvJ

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cer1tm1Belo/Cer1tm1Belo
Genetic Background: involves: 129X1/SvJ

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cer1tm1Belo/Cer1tm1Belo
Genetic Background: involves: 129X1/SvJ

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr5a2tm1Sakl/Nr5a2tm1Sakl,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6J * SJL

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cer1tm1Belo/Cer1tm1Belo
Genetic Background: involves: 129X1/SvJ

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cer1tm1Belo/Cer1tm1Belo
Genetic Background: involves: 129X1/SvJ

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cer1tm1Belo/Cer1tm1Belo
Genetic Background: involves: 129X1/SvJ

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1+,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cer1tm1Belo/Cer1tm1Belo
Genetic Background: involves: 129X1/SvJ

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cer1tm1Belo/Cer1tm1Belo
Genetic Background: involves: 129X1/SvJ

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cer1tm1Belo/Cer1tm1Belo
Genetic Background: involves: 129X1/SvJ

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cer1tm1Belo/Cer1tm1Belo
Genetic Background: involves: 129X1/SvJ

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctnnb1tm4Wbm/Ctnnb1+,Tg(KRT14-cre)1Efu/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cer1tm1Belo/Cer1tm1Belo
Genetic Background: involves: 129X1/SvJ

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cer1tm1Belo/Cer1tm1Belo
Genetic Background: involves: 129X1/SvJ

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cer1tm1Belo/Cer1tm1Belo
Genetic Background: involves: 129X1/SvJ

 MP:0008809 increased spleen iron level "increase in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cer1tm1Belo/Cer1tm1Belo
Genetic Background: involves: 129X1/SvJ

 MP:0008850 increased hemoglobin concentration distribution width "higher than normal standard deviation of the distribution of erythrocytes by their cellular (individual) hemoglobin concentrations; high HDW is indicative of some types of anemia/thalassemia" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cer1tm1Belo/Cer1tm1Belo
Genetic Background: involves: 129X1/SvJ

 MP:0009531 increased parotid gland size "increased size of either of the largest of the major salivary glands situated below and in front of each ear" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plaurtm1Mlg/Plaurtm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009568 abnormal red blood cell deformability "a measure (DImax) related to cell surface area, of the changeability of the membrane of circulating oxygen transporting cells as a function of physiologically relevant osmolality at a constant applied shear stress" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cer1tm1Belo/Cer1tm1Belo
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr