Manteia - Molecule gene

ENSMUSG00000054520

Mus musculus

Features

Gene ID:	ENSMUSG00000054520

Biological name :	Sh3bp2

Synonyms :	Sh3bp2 / SH3-domain binding protein 2

Possible biological names infered from orthology :	P78314

Species:	Mus musculus

Chr. number:	5
Strand:	1
Band:	B2
Gene start:	34525838
Gene end:	34563641

Corresponding Affymetrix probe sets:	10521205 (MoGene1.0st) 1448328_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000123177 Ensembl peptide - ENSMUSP00000112554 Ensembl peptide - ENSMUSP00000136671 Ensembl peptide - ENSMUSP00000114416 Ensembl peptide - ENSMUSP00000070890 Ensembl peptide - ENSMUSP00000098874 NCBI entrez gene - 24055 See in Manteia. MGI - MGI:1346349 RefSeq - NM_011893 RefSeq - XM_006503955 RefSeq - XM_006503954 RefSeq - NM_001145858 RefSeq - NM_001145859 RefSeq Peptide - NP_001139330 RefSeq Peptide - NP_001139331 RefSeq Peptide - NP_036023 swissprot - D6RDU0 swissprot - Q3UD40 swissprot - Q5U3L0 swissprot - E9QJU7 swissprot - D3Z107 Ensembl - ENSMUSG00000054520

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
sh3bp2	ENSDARG00000021982	Danio rerio
SH3BP2	ENSGALG00000015665	Gallus gallus
P78314	ENSG00000087266	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR000980	SH2 domain
IPR001849	Pleckstrin homology domain
IPR011993	PH-like domain superfamily
IPR035847	SH3BP2, SH2 domain
IPR035848	SH3 domain-binding protein 2
IPR036860	SH2 domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0009967	positive regulation of signal transduction	IEA
molecular_function	GO:0001784	phosphotyrosine residue binding	IEA
molecular_function	GO:0005070	SH3/SH2 adaptor activity	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000062	increased bone density	"increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Rnf146^tm1.1Rtpl/Rnf146^tm1.1Rtpl,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * BALB/cJ * C57BL/6J
MP:0000074	abnormal neurocranium morphology	"malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0000220	increased monocyte count	"greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sh3bp2^tm1.1Ics/Sh3bp2^tm1.1Ics Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0000454	abnormal jaw morphology	"malformation of the bony framework of the mouth where the teeth are held" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0000702	enlarged lymph nodes	"lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Sh3bp2^tm1.1Ics/Sh3bp2^tm1.1Ics Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001194	dermatitis	"inflammation of the skin" [J:65146]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001488	increased startle reflex	"reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0001533	abnormal skeleton physiology	"anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0001541	abnormal osteoclast function	"reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Sh3bp2^tm1Bjro/Sh3bp2⁺ Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J
MP:0001798	impaired macrophage phagocytosis	"reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sh3bp2^tm1.1Ics/Sh3bp2⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001806	decreased IgM	"less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sh3bp2^tm1Rtpl/Sh3bp2^tm1Rtpl Genetic Background: B6.129P2-Sh3bp2^tm1Rtpl
MP:0001807	decreased IgA	"less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sh3bp2^tm1Rtpl/Sh3bp2^tm1Rtpl Genetic Background: B6.129P2-Sh3bp2^tm1Rtpl
MP:0001846	increased inflammatory response	"greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * BALB/cJ * C57BL/6J Allelic Composition: Sh3bp2^tm1.1Ics/Sh3bp2^tm1.1Ics Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0001860	liver inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Csf1^op/Csf1^op,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J Allelic Composition: Nfatc1^tm3Glm/Nfatc1^tm3Glm,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0001861	lung inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Nfatc1^tm3Glm/Nfatc1^tm3Glm,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0001873	stomach inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Nfatc1^tm3Glm/Nfatc1^tm3Glm,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002116	abnormal craniofacial bone morphology	"abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002362	abnormal spleen marginal zone morphology	"anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Kat2a^tm2Roth/Kat2a^tm2Roth Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002412	increased susceptibility to bacterial infection	"greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sh3bp2^tm1.1Ics/Sh3bp2^tm1.1Ics Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0002451	abnormal macrophage physiology	"abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Sh3bp2^tm1.1Ics/Sh3bp2⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sh3bp2^tm1Rtpl/Sh3bp2^tm1Rtpl Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002458	abnormal B cell number	"deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Sh3bp2^tm1Rtpl/Sh3bp2^tm1Rtpl Genetic Background: B6.129P2-Sh3bp2^tm1Rtpl Allelic Composition: Sh3bp2^tm1Geha/Sh3bp2^tm1Geha Genetic Background: Not Specified
MP:0002459	abnormal B cell physiology	"abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdkn1c^tm1Bbd/Cdkn1c⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002460	decreased circulating immunoglobulin concentration	"less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kat2a^tm2Roth/Kat2a^tm2Roth Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0002722	abnormal immune system organ morphology	"anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002764	short tibia	" reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0002933	joint inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the joints" [RGD:Rat Genome Database submission]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0003132	increased number of pre-B cells	"greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Sh3bp2^tm1Geha/Sh3bp2^tm1Geha Genetic Background: Not Specified
MP:0003723	abnormal long bone morphology	"malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Sh3bp2^tm1Bjro/Sh3bp2⁺ Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J
MP:0003795	abnormal bone structure		Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Sh3bp2^tm1Bjro/Sh3bp2⁺ Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J
MP:0003797	abnormal compact bone morphology	"structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Sh3bp2^tm1Bjro/Sh3bp2⁺ Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J Allelic Composition: Sh3bp2^{tm1c(KOMP)Wtsi}/Sh3bp2^{tm1c(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0003865	lymph node inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lymph nodes" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Nfatc1^tm3Glm/Nfatc1^tm3Glm,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0004148	increased cortical bone thickness	"thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Sh3bp2^{tm1c(KOMP)Wtsi}/Sh3bp2^{tm1c(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0004510	myositis	"inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle" [MESH:C05.651.594]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0004978	decreased B-1 B cell number	"reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sh3bp2^tm1Rtpl/Sh3bp2^tm1Rtpl Genetic Background: B6.129P2-Sh3bp2^tm1Rtpl
MP:0004984	increased osteoclast cell number	"greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Sh3bp2^tm1Bjro/Sh3bp2⁺ Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J
MP:0004985	decreased osteoclast cell number	"reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfatc1^tm3Glm/Nfatc1^tm3Glm,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0004988	increased osteoblast cell number	"greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Sh3bp2^tm1Bjro/Sh3bp2⁺ Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J
MP:0005093	impaired B cell proliferation	"absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sh3bp2^tm1Rtpl/Sh3bp2^tm1Rtpl Genetic Background: B6.129P2-Sh3bp2^tm1Rtpl Allelic Composition: Sh3bp2^tm1Geha/Sh3bp2^tm1Geha Genetic Background: Not Specified
MP:0005190	osteomyelitis	"bone inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0005251	blepharitis	"inflammation of the eyelids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0005319	abnormal enzyme/ coenzyme level	"altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Sh3bp2^tm1Bjro/Sh3bp2⁺ Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Sh3bp2^tm1.1Ics/Sh3bp2^tm1.1Ics Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0005605	increased bone mass	"an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rnf146^tm1.1Rtpl/Rnf146^tm1.1Rtpl,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0005635	decreased circulating bilirubin level	"less thant the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Setx^{tm1b(EUCOMM)Wtsi}/Setx^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Setx^{tm1b(EUCOMM)Wtsi}/Ics
MP:0006082	CNS inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0008181	increased marginal zone B cell number	"greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]	Show Allelic Composition: Sh3bp2^tm1Rtpl/Sh3bp2^tm1Rtpl Genetic Background: B6.129P2-Sh3bp2^tm1Rtpl
MP:0008190	decreased transitional stage B cell number	"reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sh3bp2^tm1Rtpl/Sh3bp2^tm1Rtpl Genetic Background: B6.129P2-Sh3bp2^tm1Rtpl
MP:0008193	abnormal marginal zone B cell physiology	"abnormal function of a CD23-negative, CD21-positive B cell of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sh3bp2^tm1Rtpl/Sh3bp2^tm1Rtpl Genetic Background: B6.129P2-Sh3bp2^tm1Rtpl
MP:0008208	decreased pro-B cell number	"reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sh3bp2^tm1Rtpl/Sh3bp2^tm1Rtpl Genetic Background: B6.129P2-Sh3bp2^tm1Rtpl
MP:0008271	abnormal bone ossification	"any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Sh3bp2^tm1Bjro/Sh3bp2⁺ Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J
MP:0008396	abnormal osteoclast differentiation	"atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Sh3bp2^tm1Bjro/Sh3bp2⁺ Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * BALB/cJ * C57BL/6J Allelic Composition: Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro,Tnf^tm1Gkl/Tnf^tm1Gkl Genetic Background: involves: 129S/SvEv * 129S4/SvJae * BALB/cJ * C57BL/6J Allelic Composition: Nfatc1^tm3Glm/Nfatc1^tm3Glm,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA
MP:0008476	increased spleen red pulp amount	"increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0008495	decreased IgG1 level	"less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sh3bp2^tm1Rtpl/Sh3bp2^tm1Rtpl Genetic Background: B6.129P2-Sh3bp2^tm1Rtpl
MP:0008498	decreased IgG3 level	"less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sh3bp2^tm1Rtpl/Sh3bp2^tm1Rtpl Genetic Background: B6.129P2-Sh3bp2^tm1Rtpl
MP:0008553	increased circulating tumor necrosis factor level	"greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * BALB/cJ * C57BL/6J Allelic Composition: Csf1^op/Csf1^op,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J Allelic Composition: Sh3bp2^tm1.1Ics/Sh3bp2^tm1.1Ics Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0008560	increased tumor necrosis factor secretion	"increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Sh3bp2^tm1.1Ics/Sh3bp2^tm1.1Ics Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sh3bp2^tm1.1Ics/Sh3bp2⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0008561	decreased tumor necrosis factor secretion	"reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Sh3bp2^tm1Rtpl/Sh3bp2^tm1Rtpl Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008596	increased circulating interleukin-6 level	"increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Sh3bp2^tm1.1Ics/Sh3bp2^tm1.1Ics Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0008617	increased circulating interleukin-12 level	"increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]	Show Allelic Composition: Sh3bp2^tm1.1Ics/Sh3bp2^tm1.1Ics Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0008704	abnormal interleukin-6 secretion	"anomaly in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Sh3bp2^tm1Rtpl/Sh3bp2^tm1Rtpl Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008782	increased B cell apoptosis	"increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sh3bp2^tm1Rtpl/Sh3bp2^tm1Rtpl Genetic Background: B6.129P2-Sh3bp2^tm1Rtpl
MP:0008828	abnormal lymph node cell ratio	"deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]	Show Allelic Composition: Csf1^op/Csf1^op,Sh3bp2^tm1Bjro/Sh3bp2^tm1Bjro Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J
MP:0009347	increased cancellous bone thickness	"thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sh3bp2^{tm1c(KOMP)Wtsi}/Sh3bp2^{tm1c(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0010210	abnormal circulating cytokine level	"deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sh3bp2^tm1.1Ics/Sh3bp2^tm1.1Ics Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sh3bp2^tm1.1Ics/Sh3bp2⁺ Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Sh3bp2^tm1Rtpl/Sh3bp2^tm1Rtpl Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010868	increased bone trabecula number	"increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sh3bp2^{tm1c(KOMP)Wtsi}/Sh3bp2^{tm1c(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0010869	decreased bone trabecula number	"decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Sh3bp2^tm1Bjro/Sh3bp2⁺ Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J
MP:0010878	increased trabecular bone volume	"increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sh3bp2^{tm1c(KOMP)Wtsi}/Sh3bp2^{tm1c(KOMP)Wtsi} Genetic Background: involves: C57BL/6N
MP:0010879	decreased trabecular bone volume	"decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Sh3bp2^tm1Bjro/Sh3bp2⁺ Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J
MP:0013123	head/neck swellings	"appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) under the skin in the head/neck region" [MGI:Ahmad_Retha]	Show Allelic Composition: Sh3bp2^tm1.1Ics/Sh3bp2^tm1.1Ics Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0030466	alveolar process atrophy	"acquired diminution of the size of the alveolar process associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]	Show Allelic Composition: Htt^tm1.1Tna/Htt^tm1.1Tna Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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