Manteia

ENSMUSG00000054675

Mus musculus

Features

Gene ID:	ENSMUSG00000054675

Biological name :	Tmem119

Synonyms :	Q8R138 / Tmem119 / Transmembrane protein 119

Possible biological names infered from orthology :	Q4V9L6

Species:	Mus musculus

Chr. number:	5
Strand:	-1
Band:	F
Gene start:	113793729
Gene end:	113800516

Corresponding Affymetrix probe sets:	10532741 (MoGene1.0st) 1451344_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000124226 Ensembl peptide - ENSMUSP00000070551 NCBI entrez gene - 231633 See in Manteia. MGI - MGI:2385228 RefSeq - NM_146162 RefSeq - XM_006530287 RefSeq Peptide - NP_666274 swissprot - E0CYG1 swissprot - Q8R138 Ensembl - ENSMUSG00000054675

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
tmem119b	ENSDARG00000068036	Danio rerio
TMEM119	ENSGALG00000004893	Gallus gallus
Q4V9L6	ENSG00000183160	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR031453	Transmembrane protein 119

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001503	ossification	IEA
biological_process	GO:0001649	osteoblast differentiation	IMP
biological_process	GO:0007283	spermatogenesis	IMP
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0030501	positive regulation of bone mineralization	IEA
biological_process	GO:0031214	biomineral tissue development	IEA
biological_process	GO:0033690	positive regulation of osteoblast proliferation	IEA
biological_process	GO:0045669	positive regulation of osteoblast differentiation	IEA
biological_process	GO:0048515	spermatid differentiation	IMP
biological_process	GO:1903012	positive regulation of bone development	IMP
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005783	endoplasmic reticulum	IDA
cellular_component	GO:0005789	endoplasmic reticulum membrane	IEA
cellular_component	GO:0005886	plasma membrane	ISO
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000135	reduced cortical bone thickness	"thinner than normal superficial layer of compact bone " [J:61509]	Show Allelic Composition: Xcr1^tm1Ksho/Xcr1⁺ Genetic Background: involves: C57BL/6 * C57BL/6J
MP:0001146	abnormal testis morphology	"anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0001147	small testis	"reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Xcr1^tm1Ksho/Xcr1⁺ Genetic Background: involves: C57BL/6 * C57BL/6J
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Xcr1^tm1Ksho/Xcr1⁺ Genetic Background: involves: C57BL/6 * C57BL/6J
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Xcr1^tm1Ksho/Xcr1⁺ Genetic Background: involves: C57BL/6 * C57BL/6J
MP:0002059	abnormal seminal gland morphology	"anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0003419	delayed endochondral bone ossification	"late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]	Show Allelic Composition: Xcr1^tm1Ksho/Xcr1⁺ Genetic Background: involves: C57BL/6 * C57BL/6J
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Sufu^{tm1b(KOMP)Wtsi}/Sufu^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Sufu^{tm1b(KOMP)Wtsi}/Ucd
MP:0010867	abnormal bone trabecula morphology	"any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Xcr1^tm1Ksho/Xcr1⁺ Genetic Background: involves: C57BL/6 * C57BL/6J
MP:0010869	decreased bone trabecula number	"decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Xcr1^tm1Ksho/Xcr1⁺ Genetic Background: involves: C57BL/6 * C57BL/6J
MP:0010879	decreased trabecular bone volume	"decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Xcr1^tm1Ksho/Xcr1⁺ Genetic Background: involves: C57BL/6 * C57BL/6J
MP:0010933	decreased trabecular bone connectivity density	"reduction in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"]	Show Allelic Composition: Xcr1^tm1Ksho/Xcr1⁺ Genetic Background: involves: C57BL/6 * C57BL/6J
MP:0011711	decreased osteoblast differentiation		Show Allelic Composition: Xcr1^tm1Ksho/Xcr1⁺ Genetic Background: involves: C57BL/6 * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr