ENSMUSG00000055407


Mus musculus

Features
Gene ID: ENSMUSG00000055407
  
Biological name :Map6
  
Synonyms : Map6 / Microtubule-associated protein 6 / Q7TSJ2
  
Possible biological names infered from orthology : Q96JE9
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E1
Gene start: 99267447
Gene end: 99337137
  
Corresponding Affymetrix probe sets: 10555197 (MoGene1.0st)   1422550_a_at (Mouse Genome 430 2.0 Array)   1457316_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146585
Ensembl peptide - ENSMUSP00000146954
Ensembl peptide - ENSMUSP00000146897
Ensembl peptide - ENSMUSP00000064787
Ensembl peptide - ENSMUSP00000102717
Ensembl peptide - ENSMUSP00000113183
Ensembl peptide - ENSMUSP00000146340
NCBI entrez gene - 17760     See in Manteia.
MGI - MGI:1201690
RefSeq - NM_001043355
RefSeq - NM_001048167
RefSeq - NM_010837
RefSeq Peptide - NP_001036820
RefSeq Peptide - NP_034967
RefSeq Peptide - NP_001041632
swissprot - Q7TSJ2
swissprot - A0A140LIT9
swissprot - D3Z6W1
Ensembl - ENSMUSG00000055407
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map6aENSDARG00000074521Danio rerio
 map6bENSDARG00000074073Danio rerio
 MAP6ENSGALG00000007441Gallus gallus
 MAP6ENSG00000171533Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map6d1 / Q14BB9 / MAP6 domain-containing protein 1 / Q9H9H5* / MAP6 domain containing 1*ENSMUSG000000412057


Protein motifs (from Interpro)
Interpro ID Name
 IPR007882  Microtubule-associated protein 6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0032418 lysosome localization IBA
 biological_processGO:0048813 dendrite morphogenesis IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0008017 microtubule binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001361 social withdrawal "mice remain physically distant, do not sleep in piles with cagemates" [J:57125]
Show

Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Map6tm1Job/Map6+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Map6tm1Job/Map6tm1Job
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001384 abnormal pup retrieval "a mother does not retrieve stray pups to the nest or delays retrieving stray pups" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
Show

Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Map6tm1Job/Map6+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Map6tm1Job/Map6tm1Job
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0002690 akinesia "absence of movement or loss of the ability to move such as temporary or prolonged paralysis or "freezing in place"" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:82238]
Show

Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0005656 decreased aggression "when compared to controls, subjects exhibit less than the normal level of domineering, assaultive posture and/or hostile physical action" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0008911 induced hyperactivity "increased physical activity following stimulation such as handling, touching or noise" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map6tm1Job/Map6tm1Job
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map6tm1Job/Map6+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Map6tm1Job/Map6tm1Job
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Kcne1tm1Rdn/Kcne1tm1Rdn
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0013894 abnormal behavioral response to amphetamine "anomaly in the behavioral response induced by amphetamine such as induced hyperactivity or stereotypic behavior" [MGI:smb]
Show

Allelic Composition: Map6tm1Job/Map6tm1Job
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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