ENSMUSG00000055541


Mus musculus

Features
Gene ID: ENSMUSG00000055541
  
Biological name :Lair1
  
Synonyms : Lair1 / Leukocyte-associated immunoglobulin-like receptor 1 / Q8BG84
  
Possible biological names infered from orthology : LAIR2 / leukocyte associated immunoglobulin like receptor 2 / Q6GTX8 / Q6ISS4
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A1
Gene start: 4003402
Gene end: 4063204
  
Corresponding Affymetrix probe sets: 10559486 (MoGene1.0st)   1430447_a_at (Mouse Genome 430 2.0 Array)   1439067_at (Mouse Genome 430 2.0 Array)   1444040_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145940
Ensembl peptide - ENSMUSP00000070712
Ensembl peptide - ENSMUSP00000083588
Ensembl peptide - ENSMUSP00000083589
Ensembl peptide - ENSMUSP00000104241
Ensembl peptide - ENSMUSP00000116800
Ensembl peptide - ENSMUSP00000121738
Ensembl peptide - ENSMUSP00000122037
NCBI entrez gene - 52855     See in Manteia.
MGI - MGI:105492
RefSeq - XM_017322359
RefSeq - NM_001113474
RefSeq - NM_001302675
RefSeq - NM_001302676
RefSeq - NM_001302677
RefSeq - NM_001302681
RefSeq - NM_001302682
RefSeq - NM_001302683
RefSeq - NM_178611
RefSeq - XM_006540175
RefSeq - XM_006540176
RefSeq - XM_006540179
RefSeq - XM_006540183
RefSeq - XM_017322357
RefSeq - XM_017322358
RefSeq Peptide - NP_001289611
RefSeq Peptide - NP_848726
RefSeq Peptide - NP_001289610
RefSeq Peptide - NP_001289612
RefSeq Peptide - NP_001106945
RefSeq Peptide - NP_001289604
RefSeq Peptide - NP_001289605
RefSeq Peptide - NP_001289606
swissprot - Q8BG84
swissprot - G8JL64
Ensembl - ENSMUSG00000055541
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LAIR1ENSG00000167613Homo sapiens
 LAIR2ENSG00000167618Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lbric-J/Lbrlym3
Genetic Background: C57BL/6-Lbric-J/Lbrlym3

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ncr1tm1.1(icre)Viv/Ncr1tm1.1(icre)Viv
Genetic Background: involves: C57BL/6

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ncr1tm1.1(icre)Viv/Ncr1tm1.1(icre)Viv
Genetic Background: involves: C57BL/6

 MP:0010168 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010835 increased CD4-positive, alpha-beta memory T cell number "increased number of CD4-positive, alpha-beta long-lived T cells with the phenotype CD45RO-positive and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000897, GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010838 increased CD8-positive, alpha-beta memory T cell number "increased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]
Show

Allelic Composition: Asltm1Brle/Asltm1Brle
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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