ENSMUSG00000055809


Mus musculus

Features
Gene ID: ENSMUSG00000055809
  
Biological name :Dnaaf3
  
Synonyms : Dnaaf3 / Dynein assembly factor 3, axonemal / Q3UYV8
  
Possible biological names infered from orthology : AC010327.1 / dynein axonemal assembly factor 3 / Q8N9W5
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A1
Gene start: 4522933
Gene end: 4532453
  
Corresponding Affymetrix probe sets: 10559568 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000092498
NCBI entrez gene - 436022     See in Manteia.
MGI - MGI:3588207
RefSeq - NM_001033548
RefSeq - XM_006540166
RefSeq Peptide - NP_001028720
swissprot - Q3UYV8
Ensembl - ENSMUSG00000055809
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnaaf3ENSDARG00000092662Danio rerio
 dnaaf3lENSDARG00000036304Danio rerio
 AC010327.1ENSG00000267110Homo sapiens
 DNAAF3ENSG00000167646Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR027974  Domain of unknown function DUF4470
 IPR028235  Dynein assembly factor 3, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0044458 motile cilium assembly ISS
 biological_processGO:0070286 axonemal dynein complex assembly ISO
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000644 dextrocardia "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002725 abnormal vein morphology "malformation of the blood vessels that carry blood towards the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003178 left pulmonary isomerism "bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051]
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Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004113 abnormal aortic arch morphology "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004133 heterotaxia "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004158 right aortic arch "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006063 abnormal inferior vena cava morphology "structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011249 abdominal situs inversus "lateral transposition or mirroring of the viscera of the abdomen, sometimes incomplete, with all organs maintaining the normal relative position with respect to each other" [MGI:csmith]
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Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011250 abdominal situs ambiguus "an abnormality in which the abdominal organs are positioned in such a way with respect to each other and the left-right axis as to be not clearly lateralised and thus have neither the usual, or normal (situs solitus), nor the mirror-imaged (situs inversus) arrangements" [MGI:csmith, PMID:18039396]
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Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011252 situs inversus totalis "the complete right to left reversal (transposition) of the thoracic and abdominal organs, including the heart (dextrocardia)" [MGI:csmith]
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Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011649 immotile respiratory cilia "failure of the multiple epithelial tiny, motile hair-like projections of the repiratory tract epithelium to beat with a characteristic whip-like pattern in order to promote transport of fluids and other cells across the epithelium of the respiratory tract" [MGI:csmith]
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Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011683 dual inferior vena cava "presence of two inferior vena cavae, often resulting from the persistence of both supracardinal veins during development; the two structures may be symmetric or asymmetric but typically join together at the renal vein" [MGI:csmith, PMID:10835118]
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Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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