ENSMUSG00000056131


Mus musculus

Features
Gene ID: ENSMUSG00000056131
  
Biological name :Pgm3
  
Synonyms : Pgm3 / phosphoglucomutase 3 / Q9CYR6
  
Possible biological names infered from orthology : O95394
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: E3.1
Gene start: 86554377
Gene end: 86571842
  
Corresponding Affymetrix probe sets: 10595466 (MoGene1.0st)   1428228_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000070871
Ensembl peptide - ENSMUSP00000072390
NCBI entrez gene - 109785     See in Manteia.
MGI - MGI:97566
RefSeq - XM_017313098
RefSeq - NM_001163746
RefSeq - NM_028352
RefSeq Peptide - NP_082628
RefSeq Peptide - NP_001157218
swissprot - Q8BWW3
swissprot - Q9CYR6
Ensembl - ENSMUSG00000056131
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pgm3ENSDARG00000024654Danio rerio
 PGM3ENSGALG00000015854Gallus gallus
 PGM3ENSG00000013375Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005843  Alpha-D-phosphohexomutase, C-terminal
 IPR005844  Alpha-D-phosphohexomutase, alpha/beta/alpha domain I
 IPR016055  Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III
 IPR016066  Alpha-D-phosphohexomutase, conserved site
 IPR016657  Phosphoacetylglucosamine mutase
 IPR036900  Alpha-D-phosphohexomutase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006048 UDP-N-acetylglucosamine biosynthetic process IEA
 biological_processGO:0006487 protein N-linked glycosylation IEA
 biological_processGO:0006493 protein O-linked glycosylation IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0019255 glucose 1-phosphate metabolic process IDA
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0071704 organic substance metabolic process IEA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004610 phosphoacetylglucosamine mutase activity IEA
 molecular_functionGO:0004614 phosphoglucomutase activity IDA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0016868 intramolecular transferase activity, phosphotransferases IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of UDP-N-acetyl-glucosamine


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000228 abnormal thrombopoiesis "abnormal development of the non-nucleated cells of the blood (platelets, thrombocytes) involved in blood coagulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000613 abnormal salivary gland morphology "malformed saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
Show

Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008175 absent follicular B cells "absence of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009145 abnormal pancreatic acinus morphology "any structural anomaly of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gdf5Rgsc451/Gdf5+
Genetic Background: C57BL/6JJcl-Gdf5Rgsc451

 MP:0009154 pancreatic acinar hypoplasia "underdevelopment or reduced size of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced, usually due to a decreased cell number" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Pgm3Gt(W037B08)Wrst/Pgm3mld1
Genetic Background: involves: 129S1/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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