ENSMUSG00000056380


Mus musculus

Features
Gene ID: ENSMUSG00000056380
  
Biological name :Gpr50
  
Synonyms : Gpr50 / Melatonin-related receptor / O88495
  
Possible biological names infered from orthology : G protein-coupled receptor 50 / Q13585
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A7.3
Gene start: 71663667
Gene end: 71669257
  
Corresponding Affymetrix probe sets: 10600024 (MoGene1.0st)   1450346_at (Mouse Genome 430 2.0 Array)   1455498_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064608
NCBI entrez gene - 14765     See in Manteia.
MGI - MGI:1333877
RefSeq - NM_010340
RefSeq - NM_001308501
RefSeq Peptide - NP_001295430
RefSeq Peptide - NP_034470
swissprot - O88495
Ensembl - ENSMUSG00000056380
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GPR50ENSG00000102195Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mtnr1a / Q61184 / Melatonin receptor type 1A / P48039* / melatonin receptor 1A*ENSMUSG0000005476426
Mtnr1b / melatonin receptor 1B / P49286*ENSMUSG0000005090124
Gpr135 / Q7TQP2 / G protein-coupled receptor 135 / Q8IZ08*ENSMUSG0000004339812


Protein motifs (from Interpro)
Interpro ID Name
 IPR000025  Melatonin receptor family
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR002280  Melatonin-related receptor 1X
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0008502 melatonin receptor activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Mef2ctm1Jjs/Mef2ctm1Jjs,Mir223tm1Fcam/Mir223tm1Fcam,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mef2ctm1Jjs/Mef2ctm1Jjs,Mir223tm1Fcam/Mir223tm1Fcam,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mef2ctm1Jjs/Mef2ctm1Jjs,Mir223tm1Fcam/Mir223tm1Fcam,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mef2ctm1Jjs/Mef2ctm1Jjs,Mir223tm1Fcam/Mir223tm1Fcam,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Mef2ctm1Jjs/Mef2ctm1Jjs,Mir223tm1Fcam/Mir223tm1Fcam,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mef2ctm1Jjs/Mef2ctm1Jjs,Mir223tm1Fcam/Mir223tm1Fcam,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mef2ctm1Jjs/Mef2ctm1Jjs,Mir223tm1Fcam/Mir223tm1Fcam,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Mef2ctm1Jjs/Mef2ctm1Jjs,Mir223tm1Fcam/Mir223tm1Fcam,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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