ENSMUSG00000056899


Mus musculus

Features
Gene ID: ENSMUSG00000056899
  
Biological name :Immp2l
  
Synonyms : Immp2l / Mitochondrial inner membrane protease subunit 2 / Q8BPT6
  
Possible biological names infered from orthology : inner mitochondrial membrane peptidase subunit 2 / Q96T52
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: B1
Gene start: 41024090
Gene end: 41955588
  
Corresponding Affymetrix probe sets: 10395520 (MoGene1.0st)   1419495_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118779
Ensembl peptide - ENSMUSP00000116441
Ensembl peptide - ENSMUSP00000079055
NCBI entrez gene - 93757     See in Manteia.
MGI - MGI:2135611
RefSeq - NM_053122
RefSeq Peptide - NP_444352
swissprot - Q8BPT6
swissprot - K3W4P5
Ensembl - ENSMUSG00000056899
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 immp2lENSDARG00000004925Danio rerio
 ENSGALG00000027876Gallus gallus
 ENSGALG00000009485Gallus gallus
 IMMP2LENSG00000184903Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000223  Peptidase S26A, signal peptidase I
 IPR015927  Peptidase S24/S26A/S26B/S26C
 IPR019758  Peptidase S26A, signal peptidase I, conserved site
 IPR036286  LexA/Signal peptidase-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0006465 signal peptide processing IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006627 protein processing involved in protein targeting to mitochondrion IEA
 biological_processGO:0006801 superoxide metabolic process IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0008015 blood circulation IMP
 biological_processGO:0008104 protein localization ISA
 biological_processGO:0022904 respiratory electron transport chain IMP
 biological_processGO:0030728 ovulation IMP
 biological_processGO:0033108 mitochondrial respiratory chain complex assembly IMP
 biological_processGO:0061300 cerebellum vasculature development IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005743 mitochondrial inner membrane ISA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042720 mitochondrial inner membrane peptidase complex IEA
 molecular_functionGO:0008233 peptidase activity ISA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tyrc-a/Tyrc-a
Genetic Background: C3H/HeJ-Tyrc-a/J

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Tyrc-a/Tyrc-a
Genetic Background: C3H/HeJ-Tyrc-a/J

 MP:0001129 impaired ovarian folliculogenesis "a block in the formation of the spherical ovum in the ovary" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tyrc-a/Tyrc-a
Genetic Background: C3H/HeJ-Tyrc-a/J

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Tyrc-a/Tyrc-a
Genetic Background: C3H/HeJ-Tyrc-a/J

 MP:0001132 absent mature ovarian follicles "failure of ovarian follicle differentiation" [J:35782]
Show

Allelic Composition: Tyrc-a/Tyrc-a
Genetic Background: C3H/HeJ-Tyrc-a/J

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Tyrc-a/Tyrc-a
Genetic Background: C3H/HeJ-Tyrc-a/J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tyrc-a/Tyrc-a
Genetic Background: C3H/HeJ-Tyrc-a/J

Allelic Composition: Immp2lm1Btlr/Immp2lm1Btlr
Genetic Background: C57BL/6J-Immp2lm1Btlr

 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0001379 abnormal penile erection function "altered ability to achieve a rigid and elevated state of the penis when the erectile tissue becomes filled with blood " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tyrc-a/Tyrc-a
Genetic Background: C3H/HeJ-Tyrc-a/J

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Tyrc-a/Tyrc-a
Genetic Background: C3H/HeJ-Tyrc-a/J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Tyrc-a/Tyrc-a
Genetic Background: C3H/HeJ-Tyrc-a/J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Tyrc-a/Tyrc-a
Genetic Background: C3H/HeJ-Tyrc-a/J

 MP:0002750 exophthalmos "protrusion of one or both eyeballs" [J:47965, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0004918 abnormal negative T cell selection "any anomaly in the process of elimination of immature T cells which react strongly with self-antigens" [GO:0043383]
Show

Allelic Composition: Lgals3tm1Poi/Lgals3tm1Poi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
Show

Allelic Composition: Lgals3tm1Poi/Lgals3tm1Poi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0005078 abnormal cytotoxic T cell physiology "impaired function of the subset of CD8+ T lymphocytes capable of directly killing appropriately targeted cells " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lgals3tm1Poi/Lgals3tm1Poi
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tyrc-a/Tyrc-a
Genetic Background: C3H/HeJ-Tyrc-a/J

 MP:0010016 variable depigmentation "absence or loss of normal pigment in the skin in various and irregular patterns" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0010274 increased organ/body region tumor incidence "greater than the expected number of tumors originating in a specific body region or organ in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0010275 increased melanoma incidence "greater than the expected number of malignant neoplasms, derived from melanocytes and occuring in pigmented tissues, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0010295 increased eye tumor incidence "greater than the expected number of tumors originating in the eye in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkcbtilc/Prkcbtilc
Genetic Background: C57BL/6JSfdAnu-Prkcbtilc/Apb

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
Show

Allelic Composition: Tyrc-a/Tyrc-a
Genetic Background: C3H/HeJ-Tyrc-a/J

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
Show

Allelic Composition: Tyrc-a/Tyrc-a
Genetic Background: C3H/HeJ-Tyrc-a/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr