ENSMUSG00000057054


Mus musculus

Features
Gene ID: ENSMUSG00000057054
  
Biological name :Inca1
  
Synonyms : Inca1 / Protein INCA1 / Q6PKN7
  
Possible biological names infered from orthology : inhibitor of CDK, cyclin A1 interacting protein 1 / Q0VD86
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 70688361
Gene end: 70700155
  
Corresponding Affymetrix probe sets: 10387971 (MoGene1.0st)   1445568_at (Mouse Genome 430 2.0 Array)   1448034_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000073311
Ensembl peptide - ENSMUSP00000104181
Ensembl peptide - ENSMUSP00000104182
Ensembl peptide - ENSMUSP00000104183
Ensembl peptide - ENSMUSP00000118761
NCBI entrez gene - 103844     See in Manteia.
MGI - MGI:2144284
RefSeq - XM_017314212
RefSeq - NM_001252482
RefSeq - NM_001252483
RefSeq - NM_001252484
RefSeq - NM_001252485
RefSeq - NM_213729
RefSeq - XM_006531926
RefSeq - XM_006531928
RefSeq - XM_006531929
RefSeq Peptide - NP_998894
RefSeq Peptide - NP_001239411
RefSeq Peptide - NP_001239412
RefSeq Peptide - NP_001239413
RefSeq Peptide - NP_001239414
swissprot - Q6PKN7
Ensembl - ENSMUSG00000057054
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 INCA1ENSG00000196388Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026238  Protein INCA1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IGI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016604 nuclear body ISO
 molecular_functionGO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity IBA
 molecular_functionGO:0030332 cyclin binding ISO
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mybl1repro9/Mybl1tm1Epr
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Mybl1repro9/Mybl1tm1Epr
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Mybl1repro9/Mybl1tm1Epr
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mybl1repro9/Mybl1tm1Epr
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: Mybl1repro9/Mybl1tm1Epr
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
Show

Allelic Composition: Mybl1repro9/Mybl1tm1Epr
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Mybl1repro9/Mybl1tm1Epr
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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