| MP:0000288 | abnormal pericardium morphology | "malformation of the fibroserous membrane covering the heart and beginning of the great vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:54408] |
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt
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| MP:0000428 | abnormal craniofacial morphology | "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt
Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0000603 | pale liver | "liver lacking normal coloration, often refers to bloodless condition" [J:18048] |
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt
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| MP:0000774 | reduced brain size | "smaller appearance of the brain" [J:35802] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0000788 | abnormal cerebral cortex morphology | "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0000790 | abnormal stratification in cerebral cortex | "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0001606 | impaired hematopoiesis | "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0001785 | edema | "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065] |
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt
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| MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt
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| MP:0003172 | abnormal lysosome physiology | "ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0003241 | loss of cortex neurons | "loss of neurons in the cortex region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0004808 | abnormal hematopoietic stem cell morphology | "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0004809 | increased hematopoietic stem cell number | "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0005058 | abnormal lysosome morphology | "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0005650 | abnormal limb bud morphology | "aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460] |
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt
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| MP:0006254 | thin cerebral cortex | "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0008441 | thin cortical plate | "reduced thickness of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0008457 | abnormal cortical intermediate zone morphology | "any structural anomaly of the region of the developing mammalian cortex that extends between the ventricular zone and the cortical plate (CP); normally, the IZ is a region of tangential migration of cells, and at midgestation, the lower part of the IZ develops into the subventricular zone" [PMID:10632599] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0008480 | absent eye pigmentation | "absence of melanin (pigment) in the eye either due to absent melanocytes or failure of melanin synthesis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0008535 | enlarged lateral ventricles | "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0008546 | abnormal vesicle-mediated transport | "anomaly in the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell" [GO:0016192] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0011100 | complete preweaning lethality | "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt
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| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0011827 | impaired neuron differentiation | "decreased production of or inability to produce the mature cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0011902 | increased hematopoietic stem cell proliferation | "increase in the expansion rate of a hematopoietic stem cell population by cell division" [MGI:csmith] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0013293 | embryonic lethality prior to tooth bud stage | "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb] |
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt
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| MP:0013294 | prenatal lethality prior to heart atrial septation | "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb] |
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt
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| MP:0013697 | decreased granulocyte monocyte progenitor cell number | "reduction in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1" [CL:0000557, PMID:16551251] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0020389 | increased radial glial cell number | "increase in the number of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [MGI:anna, PMID:25100583] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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| MP:0020393 | increased neuronal precursor proliferation | "increase in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:anna] |
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Allelic Composition: Bloc1s2tm1Wli/Bloc1s2tm1Wli
Genetic Background: involves: 129 * C57BL/6J
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