ENSMUSG00000057531


Mus musculus

Features
Gene ID: ENSMUSG00000057531
  
Biological name :Dtnbp1
  
Synonyms : Dtnbp1 / Dysbindin / Q91WZ8
  
Possible biological names infered from orthology : dystrobrevin binding protein 1 / Q96EV8
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A5
Gene start: 44922075
Gene end: 45002147
  
Corresponding Affymetrix probe sets: 10408915 (MoGene1.0st)   1431619_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152195
Ensembl peptide - ENSMUSP00000152863
Ensembl peptide - ENSMUSP00000152855
Ensembl peptide - ENSMUSP00000152812
Ensembl peptide - ENSMUSP00000152706
Ensembl peptide - ENSMUSP00000152407
Ensembl peptide - ENSMUSP00000152362
Ensembl peptide - ENSMUSP00000072170
Ensembl peptide - ENSMUSP00000105755
NCBI entrez gene - 94245     See in Manteia.
MGI - MGI:2137586
RefSeq - NM_025772
RefSeq Peptide - NP_080048
swissprot - A0A1Y7VK42
swissprot - A0A1Y7VJD2
swissprot - A0A1Y7VIX4
swissprot - K3W4R3
swissprot - A0A1Y7VP73
swissprot - Q91WZ8
swissprot - A0A1Y7VND4
swissprot - A0A1Y7VKA2
Ensembl - ENSMUSG00000057531
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dtnbp1bENSDARG00000055206Danio rerio
 DTNBP1ENSGALG00000012703Gallus gallus
 DTNBP1ENSG00000047579Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dbndd2 / Q9CRD4 / Dysbindin domain-containing protein 2 / Q9BQY9* / dysbindin domain containing 2*ENSMUSG0000001773416


Protein motifs (from Interpro)
Interpro ID Name
 IPR007531  Dysbindin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001956 positive regulation of neurotransmitter secretion IMP
 biological_processGO:0006996 organelle organization IDA
 biological_processGO:0007517 muscle organ development TAS
 biological_processGO:0007596 blood coagulation IMP
 biological_processGO:0008089 anterograde axonal transport IMP
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0014059 regulation of dopamine secretion IMP
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IDA
 biological_processGO:0032091 negative regulation of protein binding IMP
 biological_processGO:0043506 regulation of JUN kinase activity IMP
 biological_processGO:0048490 anterograde synaptic vesicle transport IMP
 biological_processGO:0048812 neuron projection morphogenesis IDA
 biological_processGO:0048813 dendrite morphogenesis IMP
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0060155 platelet dense granule organization IMP
 biological_processGO:0060159 regulation of dopamine receptor signaling pathway ISS
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0014069 postsynaptic density ISO
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016528 sarcoplasm IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030426 growth cone IDA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0030672 synaptic vesicle membrane ISO
 cellular_componentGO:0031083 BLOC-1 complex IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0033162 melanosome membrane IEA
 cellular_componentGO:0042383 sarcolemma IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:1904115 axon cytoplasm IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Golgi Associated Vesicle Biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptstm1Thny/Ptstm1Thny
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dtnbp1sdy-Btlr/Dtnbp1sdy-Btlr
Genetic Background: C57BL/6J-Dtnbp1sdy-Btlr

Allelic Composition: Dtnbp1sdy/Dtnbp1sdy
Genetic Background: DBA/2J-Dtnbp1sdy/J

 MP:0001102 small superior vagus ganglion "reduced size of the upper ganglion of the vagus nerve located at the jugular foramen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0001324 abnormal eye pigmentation "change in the normal black pigmentation of the eye to another color, or lack of color" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptstm1Thny/Ptstm1Thny
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Dtnbp1sdy/Dtnbp1+
Genetic Background: DBA/2J-Dtnbp1sdy/J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Dtnbp1sdy/Dtnbp1+
Genetic Background: DBA/2J-Dtnbp1sdy/J

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptstm1Thny/Ptstm1Thny
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dtnbp1sdy-Btlr/Dtnbp1sdy-Btlr
Genetic Background: C57BL/6J-Dtnbp1sdy-Btlr

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptstm1Thny/Ptstm1Thny
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002800 abnormal short-term recognition memory "defects in the short-term memory for objects is established during the first few minutes after training" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Dtnbp1sdy/Dtnbp1sdy
Genetic Background: DBA/2J-Dtnbp1sdy/J

Allelic Composition: Dtnbp1sdy/Dtnbp1+
Genetic Background: DBA/2J-Dtnbp1sdy/J

 MP:0002803 abnormal operant conditional behavior "defects in the operant conditioning system refers to abnormalities in scheduled controlled behavior; behavioral assessment occurs in an automated chamber where responses are reinforced with food" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Dtnbp1sdy/Dtnbp1+
Genetic Background: DBA/2J-Dtnbp1sdy/J

 MP:0003043 hypoalgesia "decreased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Dtnbp1sdy/Dtnbp1sdy
Genetic Background: DBA/2J-Dtnbp1sdy/J

Allelic Composition: Dtnbp1sdy/Dtnbp1+
Genetic Background: DBA/2J-Dtnbp1sdy/J

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Ptstm1Thny/Ptstm1Thny
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004725 decreased platelet serotonin level "reduced concentration of serotonin in the platelets; this biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ptstm1Thny/Ptstm1Thny
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Dtnbp1sdy-Btlr/Dtnbp1sdy-Btlr
Genetic Background: C57BL/6J-Dtnbp1sdy-Btlr

 MP:0005098 abnormal choroid morphology "anomalous structure of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ptstm1Thny/Ptstm1Thny
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005102 abnormal iris pigmentation "anomalous coloring of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0005172 lack of eye pigmentation "visual organs are devoid of coloring pigment in relation to control animals, usually resulting in a red or pink color" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
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Allelic Composition: Dtnbp1sdy/Dtnbp1sdy
Genetic Background: DBA/2J-Dtnbp1sdy/J

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptstm1Thny/Ptstm1Thny
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptstm1Thny/Ptstm1Thny
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Dtnbp1sdy/Dtnbp1sdy
Genetic Background: DBA/2J-Dtnbp1sdy/J

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dtnbp1sdy/Dtnbp1+
Genetic Background: DBA/2J-Dtnbp1sdy/J

 MP:0009455 enhanced cued conditioning behavior "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dtnbp1sdy/Dtnbp1sdy
Genetic Background: DBA/2J-Dtnbp1sdy/J

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Ptstm1Thny/Ptstm1Thny
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010193 abnormal choroid melanin granule morphology "any structural anomaly of the pigment particles in the choroid" [ISBN-13:978-1-4051-2034-0 "The Pigmentary System, Second Edition"]
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Allelic Composition: Ptstm1Thny/Ptstm1Thny
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011620 abnormal habituation to a new environment "anomaly in the process in which there is a progressive decline of behavioral response probability with an exposure to a new environment" [MGI:csmith]
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Allelic Composition: Dtnbp1sdy/Dtnbp1sdy
Genetic Background: DBA/2J-Dtnbp1sdy/J

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0013894 abnormal behavioral response to amphetamine "anomaly in the behavioral response induced by amphetamine such as induced hyperactivity or stereotypic behavior" [MGI:smb]
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Allelic Composition: Dtnbp1sdy/Dtnbp1sdy
Genetic Background: DBA/2J-Dtnbp1sdy/J

 MP:0020432 decreased platelet dense granule number "decreased number of the electron-dense bodies occurring in blood platelets that store and secrete adenosine nucleotides and serotonin" [orcid.org/0000-0003-4606-0597]
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Allelic Composition: Ptstm1Thny/Ptstm1Thny
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
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Allelic Composition: Dtnbp1sdy/Dtnbp1+
Genetic Background: DBA/2J-Dtnbp1sdy/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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