ENSMUSG00000057666


Mus musculus

Features
Gene ID: ENSMUSG00000057666
  
Biological name :Gapdh
  
Synonyms : Gapdh / Glyceraldehyde-3-phosphate dehydrogenase / P16858
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F2
Gene start: 125161715
Gene end: 125166467
  
Corresponding Affymetrix probe sets: 1418625_s_at (Mouse Genome 430 2.0 Array)   1447999_x_at (Mouse Genome 430 2.0 Array)   1457612_at (Mouse Genome 430 2.0 Array)   AFFX-GapdhMur/M32599_3_at (Mouse Genome 430 2.0 Array)   AFFX-GapdhMur/M32599_M_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138295
Ensembl peptide - ENSMUSP00000113942
Ensembl peptide - ENSMUSP00000138403
Ensembl peptide - ENSMUSP00000138508
Ensembl peptide - ENSMUSP00000073289
Ensembl peptide - ENSMUSP00000113213
NCBI entrez gene - 14433     See in Manteia.
NCBI entrez gene - 100042025     See in Manteia.
MGI - MGI:95640
RefSeq - NM_008084
RefSeq - XM_017321385
RefSeq - NM_001289726
RefSeq Peptide - NP_032110
RefSeq Peptide - NP_001276655
swissprot - D2KHZ9
swissprot - P16858
swissprot - S4R1N5
swissprot - S4R1W8
swissprot - S4R257
swissprot - A0A0A0MQF6
Ensembl - ENSMUSG00000057666
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gapdhENSDARG00000043457Danio rerio
 GAPDHENSGALG00000014442Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm3839ENSMUSG0000009714892
Gm10358ENSMUSG0000011046992
Gapdhs / glyceraldehyde-3-phosphate dehydrogenase, spermatogenic / O14556*ENSMUSG0000006109966
Gm11214ENSMUSG0000009929445
Gm12117ENSMUSG0000009845634
Gm15294 / GAPDH* / P04406* / glyceraldehyde-3-phosphate dehydrogenase*ENSMUSG0000008160727


Protein motifs (from Interpro)
Interpro ID Name
 IPR006424  Glyceraldehyde-3-phosphate dehydrogenase, type I
 IPR020828  Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain
 IPR020829  Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain
 IPR020830  Glyceraldehyde 3-phosphate dehydrogenase, active site
 IPR020831  Glyceraldehyde/Erythrose phosphate dehydrogenase family
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization ISS
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006096 glycolytic process IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007275 multicellular organism development IMP
 biological_processGO:0010951 negative regulation of endopeptidase activity ISO
 biological_processGO:0017148 negative regulation of translation ISO
 biological_processGO:0031640 killing of cells of other organism ISO
 biological_processGO:0035606 peptidyl-cysteine S-trans-nitrosylation ISS
 biological_processGO:0050715 positive regulation of cytokine secretion ISO
 biological_processGO:0050821 protein stabilization ISS
 biological_processGO:0050832 defense response to fungus ISO
 biological_processGO:0051402 neuron apoptotic process ISS
 biological_processGO:0051873 killing by host of symbiont cells ISO
 biological_processGO:0052501 positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide ISO
 biological_processGO:0071346 cellular response to interferon-gamma ISO
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005811 lipid droplet ISO
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0015630 microtubule cytoskeleton ISS
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0031965 nuclear membrane ISO
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0097452 GAIT complex ISO
 molecular_functionGO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding ISS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019828 aspartic-type endopeptidase inhibitor activity ISO
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0035605 peptidyl-cysteine S-nitrosylase activity ISS
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0050661 NADP binding IEA
 molecular_functionGO:0051287 NAD binding IEA
 molecular_functionGO:0097718 disordered domain specific binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002596 abnormal hematocrit "greater or less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: GapdhM5Neu/GapdhM5Neu
Genetic Background: C3.Cg-GapdhM5Neu

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: GapdhM5Neu/GapdhM5Neu
Genetic Background: C3.Cg-GapdhM5Neu

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Metap2tm1.1Ccr/Metap2tm1.1Ccr,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Gapdhm2Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

Allelic Composition: Gapdhm3Neu/Gapdhm3Neu
Genetic Background: involves: 101/El * C3H/El

Allelic Composition: Gapdhm3Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: involves: 101/El * C3H/El

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gapdhm2Neu/Gapdh+
Genetic Background: C3.Cg-Gapdhm2Neu

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Metap2tm1.1Ccr/Metap2tm1.1Ccr,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6

Allelic Composition: Gapdhm2Neu/Gapdhm2Neu
Genetic Background: involves: 101/El * C3H/El

Allelic Composition: Gapdhm3Neu/Gapdhm3Neu
Genetic Background: involves: 101/El * C3H/El

Allelic Composition: Gapdhm4Neu/Gapdhm4Neu
Genetic Background: involves: 101/El * C3H/El

Allelic Composition: Gapdhm3Neu/Gapdhm3Neu
Genetic Background: C3.Cg-Gapdhm3Neu

Allelic Composition: GapdhM5Neu/GapdhM5Neu
Genetic Background: C3.Cg-GapdhM5Neu

Allelic Composition: GapdhM6Neu/GapdhM6Neu
Genetic Background: C3.Cg-GapdhM6Neu

Allelic Composition: GapdhM7Neu/GapdhM7Neu
Genetic Background: C3.Cg-GapdhM7Neu

Allelic Composition: GapdhM8Neu/GapdhM8Neu
Genetic Background: C3.Cg-GapdhM8Neu

Allelic Composition: GapdhM9Neu/GapdhM9Neu
Genetic Background: C3.Cg-GapdhM9Neu

 MP:0011106 partial embryonic lethality before somite formation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Zfp568Gt(RRU161)Byg/Zfp568chato
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gapdhm2Neu/Gapdhm2Neu
Genetic Background: C3.Cg-Gapdhm2Neu

Allelic Composition: Gapdhm4Neu/Gapdhm4Neu
Genetic Background: C3.Cg-Gapdhm4Neu

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gapdhm3Neu/Gapdh+
Genetic Background: C3.Cg-Gapdhm3Neu

Allelic Composition: GapdhM6Neu/Gapdh+
Genetic Background: C3.Cg-GapdhM6Neu

 MP:0011609 decreased glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity "reduced ability to catalyze the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+" [GO:0004365]
Show

Allelic Composition: Zfp568Gt(RRU161)Byg/Zfp568chato
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gapdhm2Neu/Gapdh+
Genetic Background: C3.Cg-Gapdhm2Neu

Allelic Composition: Gapdhm3Neu/Gapdhm3Neu
Genetic Background: C3.Cg-Gapdhm3Neu

Allelic Composition: Gapdhm3Neu/Gapdh+
Genetic Background: C3.Cg-Gapdhm3Neu

Allelic Composition: Gapdhm4Neu/Gapdh+
Genetic Background: C3.Cg-Gapdhm4Neu

Allelic Composition: GapdhM5Neu/Gapdh+
Genetic Background: C3.Cg-GapdhM5Neu

Allelic Composition: GapdhM6Neu/Gapdh+
Genetic Background: C3.Cg-GapdhM6Neu

Allelic Composition: GapdhM7Neu/Gapdh+
Genetic Background: C3.Cg-GapdhM7Neu

Allelic Composition: GapdhM8Neu/Gapdh+
Genetic Background: C3.Cg-GapdhM8Neu

Allelic Composition: GapdhM9Neu/Gapdh+
Genetic Background: C3.Cg-GapdhM9Neu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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