ENSMUSG00000058298


Mus musculus

Features
Gene ID: ENSMUSG00000058298
  
Biological name :Mcm9
  
Synonyms : Mcm9 / minichromosome maintenance 9 homologous recombination repair factor / Q2KHI9
  
Possible biological names infered from orthology : Q9NXL9
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B3
Gene start: 53536315
Gene end: 53630439
  
Corresponding Affymetrix probe sets: 10369116 (MoGene1.0st)   1430563_at (Mouse Genome 430 2.0 Array)   1437575_at (Mouse Genome 430 2.0 Array)   1447969_at (Mouse Genome 430 2.0 Array)   1455117_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151893
Ensembl peptide - ENSMUSP00000151639
Ensembl peptide - ENSMUSP00000151956
Ensembl peptide - ENSMUSP00000151878
Ensembl peptide - ENSMUSP00000074978
Ensembl peptide - ENSMUSP00000151573
NCBI entrez gene - 71567     See in Manteia.
MGI - MGI:1918817
RefSeq - XM_006512856
RefSeq - XM_006512857
RefSeq - XM_011243206
RefSeq - XM_017314097
RefSeq - XM_017314098
RefSeq - NM_027830
RefSeq Peptide - NP_082106
swissprot - Q3V0E3
swissprot - A0A1W2P801
swissprot - A0A1W2P7E8
swissprot - Q2KHI9
swissprot - A0A1W2P804
Ensembl - ENSMUSG00000058298
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcm9ENSDARG00000013528Danio rerio
 MCM9ENSGALG00000014883Gallus gallus
 MCM9ENSG00000111877Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mcm7 / Q61881 / minichromosome maintenance complex component 7 / P33993*ENSMUSG0000002973016


Protein motifs (from Interpro)
Interpro ID Name
 IPR001208  MCM domain
 IPR003593  AAA+ ATPase domain
 IPR012340  Nucleic acid-binding, OB-fold
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031327  Mini-chromosome maintenance protein
 IPR033762  MCM OB domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006270 DNA replication initiation IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007276 gamete generation IMP
 biological_processGO:0007292 female gamete generation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0097362 MCM8-MCM9 complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001128 ovary hyperplasia "increased cell number in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

Allelic Composition: Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm9Gt(AW0655)Wtsi/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

Allelic Composition: Mcm9tm1.1Geno/Mcm9tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
Show

Allelic Composition: Psen1tm1.1Ruvi/Psen1tm1.1Ruvi,Tg(APP)8.9Btla/0
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

Allelic Composition: Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm9Gt(AW0655)Wtsi/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

Allelic Composition: Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm9Gt(AW0655)Wtsi/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm9tm1.1Geno/Mcm9tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

Allelic Composition: Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm9Gt(AW0655)Wtsi/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm9tm1.1Geno/Mcm9tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mcm9tm1.1Geno/Mcm9tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

Allelic Composition: Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm9Gt(AW0655)Wtsi/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0003507 abnormal ovary physiology "anomaly or loss either the production of female germ cells or the endocrine cells for the production of estrogen and progesterone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mcm9tm1.1Geno/Mcm9tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004029 spontaneous chromosome breakage "chromosome breakage due to inherent instability of chromosomes" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm9tm1.1Geno/Mcm9tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

Allelic Composition: Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm9Gt(AW0655)Wtsi/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0006361 abnormal female germ cell morphology "any structural anomaly female germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

Allelic Composition: Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm9Gt(AW0655)Wtsi/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0008000 ovary tumor "presence of abnormal rapidly proliferating cells in the ovary, usually in the form of a distinct mass" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

Allelic Composition: Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm9Gt(AW0655)Wtsi/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0008057 abnormal DNA replication "any anomaly in the process whereby new strands of DNA are synthesized" [GO:0006260]
Show

Allelic Composition: Mcm9tm1.1Geno/Mcm9tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

Allelic Composition: Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

Allelic Composition: Mcm9Gt(AW0655)Wtsi/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mcm9tm1.1Geno/Mcm9tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0008871 abnormal ovarian follicle number "abnormal numbers of spheroid cell aggregations in the ovary" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0010383 increased adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:C04.557.470.035]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Atg7tm1Tchi/Atg7tm1Tchi,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj

 MP:0011121 decreased primordial ovarian follicle number "fewer than normal numbers of the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:csmith]
Show

Allelic Composition: Mcm9Gt(XG743)Byg/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Mcm9tm1.1Geno/Mcm9tm1.1Geno
Genetic Background: involves: 129S2/SvPas * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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