ENSMUSG00000058499


Mus musculus

Features
Gene ID: ENSMUSG00000058499
  
Biological name :Pip
  
Synonyms : P02816 / Pip / prolactin induced protein
  
Possible biological names infered from orthology : P12273
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B2.1
Gene start: 41847535
Gene end: 41852065
  
Corresponding Affymetrix probe sets: 10537679 (MoGene1.0st)   1427614_at (Mouse Genome 430 2.0 Array)   1449212_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000074818
Ensembl peptide - ENSMUSP00000144995
Ensembl peptide - ENSMUSP00000144926
NCBI entrez gene - 18716     See in Manteia.
MGI - MGI:102696
RefSeq - NM_008843
RefSeq Peptide - NP_032869
swissprot - A0A0N4SV27
swissprot - A0A0N4SV85
swissprot - P02816
swissprot - Q3UU48
Ensembl - ENSMUSG00000058499
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PIPENSG00000159763Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007990  Prolactin-inducible protein
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste ISO
 biological_processGO:0002682 regulation of immune system process IMP
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0070233 negative regulation of T cell apoptotic process ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0016324 apical plasma membrane IDA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019864 IgG binding ISO
 molecular_functionGO:0046983 protein dimerization activity ISO


Pathways (from Reactome)
Pathway description
Miscellaneous transport and binding events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0002742 enlarged submandibular lymph nodes "increased size of the submandibular lymph nodes" [J:69405, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0009381 abnormal dorsolateral prostate morphology 
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0009543 abnormal thymus corticomedullary boundary morphology "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0010138 arteritis "inflammation of the walls of arteries, usually as a result of infection or auto-immune response" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

 MP:0013590 enlarged thymus medulla "increased size of the inner area of thymus lobules" [MGI:Anna]
Show

Allelic Composition: Npr1tm1.1Rsha/Npr1+
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000037053 Azgp1 / Q64726 / Zinc-alpha-2-glycoprotein / P25311* / alpha-2-glycoprotein 1, zinc-binding*  / reaction / complex






 

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