ENSMUSG00000058761


Mus musculus

Features
Gene ID: ENSMUSG00000058761
  
Biological name :Rnf169
  
Synonyms : E3 ubiquitin-protein ligase RNF169 / E9Q7F2 / Rnf169
  
Possible biological names infered from orthology : Q8NCN4 / ring finger protein 169
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E2
Gene start: 99920254
Gene end: 99980448
  
Corresponding Affymetrix probe sets: 10565852 (MoGene1.0st)   1434207_at (Mouse Genome 430 2.0 Array)   1434208_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079631
NCBI entrez gene - 108937     See in Manteia.
MGI - MGI:1920257
RefSeq - XM_006507187
RefSeq - NM_175388
RefSeq - XM_006507185
RefSeq Peptide - NP_780597
swissprot - E9Q7F2
Ensembl - ENSMUSG00000058761
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 E7FAP1ENSDARG00000042825Danio rerio
 RNF169ENSGALG00000017309Gallus gallus
 Q8NCN4ENSG00000166439Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:2000780 negative regulation of double-strand break repair IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISS
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0035861 site of double-strand break IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031491 nucleosome binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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