ENSMUSG00000059325


Mus musculus

Features
Gene ID: ENSMUSG00000059325
  
Biological name :Hopx
  
Synonyms : Homeodomain-only protein / Hopx / Q8R1H0
  
Possible biological names infered from orthology : HOP homeobox / Q9BPY8
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: C3.3
Gene start: 77086988
Gene end: 77115121
  
Corresponding Affymetrix probe sets: 10530819 (MoGene1.0st)   1428662_a_at (Mouse Genome 430 2.0 Array)   1451776_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000080630
Ensembl peptide - ENSMUSP00000109080
Ensembl peptide - ENSMUSP00000113295
NCBI entrez gene - 74318     See in Manteia.
MGI - MGI:1916782
RefSeq - NM_001159901
RefSeq - NM_001159900
RefSeq - NM_175606
RefSeq Peptide - NP_001153372
RefSeq Peptide - NP_001153373
RefSeq Peptide - NP_783199
swissprot - Q8R1H0
Ensembl - ENSMUSG00000059325
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hopxENSDARG00000089368Danio rerio
 HOPXENSGALG00000011404Gallus gallus
 HOPXENSG00000171476Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0001829 trophectodermal cell differentiation ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0016575 histone deacetylation IGI
 biological_processGO:0043393 regulation of protein binding IDA
 biological_processGO:0043415 positive regulation of skeletal muscle tissue regeneration IMP
 biological_processGO:0045596 negative regulation of cell differentiation ISO
 biological_processGO:0048286 lung alveolus development IMP
 biological_processGO:0051131 chaperone-mediated protein complex assembly ISO
 biological_processGO:0051155 positive regulation of striated muscle cell differentiation IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0000275 heart hyperplasia "increased cell number in the heart" [J:18048]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0001182 lung hemorrhage "bleeding in the respiratory organs" [J:66345]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004071 prolonged P wave "increase in the length of time of the P wave electrical impulses" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004072 abnormal frontal plane axis "any anomaly found in the sum of all electrical currents in the heart during systole" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S6/SvEvTac

 MP:0005586 decreased tidal volume "less than the normal volume of air inspired or expired during each normal respiratory cycle" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
Show

Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006321 increased myocardial fiber number "increased number of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S6/SvEvTac

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010553 prolonged HV interval "increase in the length of time from the initial deflection of the His bundle (H) potential and the onset of ventricular activity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010560 intraventricular block "absent or delayed conduction within the ventricular conducting system or in the ventricular myocardium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010992 increased surfactant secretion "greater production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S6/SvEvTac

 MP:0011142 abnormal lung-associated mesenchyme development "abnormality in the formation of the lung tissue comprised of multiple cell types (including connective tissue, endothelial cells, lymphatics, smooth muscle cells surrounding airways and blood vessels, myofibroblasts involved in septum formation, and cartilage-forming cells in the trachea), with most cells thought to be derived from the splanchnic mesenchyme, and other cells (endothelial, smooth muscle) believed to invade the lung as it expands; lung mesenchyme is a critical determinant of the shape and size of the developing lung, the extent and patterning of epithelial branching, and the formation of the pulmonary vasculature and interstitial mesenchymal components of the adult lung" [MGI:anna, PMID:18533146, PMID:20048339]
Show

Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011143 thick lung-associated mesenchyme "increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development" [MGI:anna]
Show

Allelic Composition: Hopxtm1.1Joe/Hopxtm1.1Joe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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